2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. GW 833972A

GW 833972A 是一种选择性的 CB2 受体 (CB2 receptor) 完全激动剂，对人源 CB2 受体的 pEC₅₀ 为 7.3，对 CB2 受体的选择性比对 CB1 受体高约 1000 倍。GW 833972A 抑制受诱导神经去极化，并在豚鼠模型中抑制柠檬酸引起的咳嗽。GW 833972A 可用于研究慢性咳嗽。

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GW 833972A

GW 833972A Chemical Structure

CAS No. : 1092502-33-4

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规格 价格 是否有货 数量
1 mg ￥1050
In-stock
5 mg ￥2100
In-stock
10 mg ￥3350
In-stock
25 mg 现货 询价
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Other Forms of GW 833972A:

GW 833972A 相关抗体

Top Publications Citing Use of Products

查看 Cannabinoid Receptor 亚型特异性产品:

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CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW 833972A is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough[1].

IC50 & Target[1]

hCB2-R

7.3 (pEC50)

rat CB2-R

7.5 (pEC50)

体外研究
(In Vitro)

GW 833972A (0.3-300 μM; 10 min) inhibits capsaicin-induced depolarization in humans and guinea pigs, and also inhibits prostaglandin E(2) and hypertonic saline induced depolarization of isolated vagus nerve in guinea pigs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GW 833972A 相关抗体:
体内研究
(In Vivo)

GW 833972A (30 mg/kg, 2 mL/kg; i.p.; single dose 30 min before test) inhibits tussive response in conscious guinea pigs induced by citric acid. It also inhibits capsaicin-induced plasma protein exudation in the main bronchus[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

444.24

Formula

C18H14Cl2F3N5O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.91%

COA (289 KB) HNMR (137 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

GW 833972A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 833972A1092502-33-4Cannabinoid ReceptorInhibitorinhibitorinhibit

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产品名称：
GW 833972A
目录号：
HY-101765
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