2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC degrader-2

HDAC degrader-2 是一种选择性 HDAC 降解剂，其对 HDAC1 的 DC50 值为 2.55 μM。HDAC degrader-2 可有效诱导 HDAC1 和 HDAC2 的降解，但对 HDAC3、4、6 和 8 的降解无显著影响。HDAC degrader-2 对 MM.1S 和 MCF-7 细胞具有强大的抗增殖作用。HDAC degrader-2 可诱导骨髓瘤细胞凋亡 (apoptosis)。HDAC degrader-2 可用于骨髓瘤的研究。

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HDAC degrader-2

HDAC degrader-2 Chemical Structure

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HDAC degrader-2 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma[1].

IC50 & Target[1]

HDAC1

2.55 μM (DC50)

HDAC2

 

体外研究
(In Vitro)

HDAC-degrader 2 (Compound SZ-2) (24 h) 对 MM.1S (IC50 = 3.28 μM) 和 MCF-7 (IC50 = 3.46 μM) 细胞表现出强大的抗增殖作用[1]。
HDAC-degrader 2 (5 μM, 48 h) 显著诱导 MM.1S 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC degrader-2 相关抗体:

Apoptosis Analysis[1]

Cell Line: MM.1S cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly increased the percentages of early and late apoptotic cells.
分子量

591.10

Formula

C32H35ClN4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC degrader-2HDAC degrader2HDAC degrader 2HDACApoptosisHistone deacetylasesHistone deacetylase (HDAC)CancerDamage-specific DNA binding protein 1 (DDB1)Proteolysis targeting chimeras (PROTACs)Targeted Protein Degradation (TPD)Inhibitorinhibitorinhibit

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产品名称：
HDAC degrader-2
目录号：
HY-178161
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