2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis Bcl-2 Family CDK
  4. HDAC-IN-51

HDAC-IN-51 是一种有效的组蛋白脱乙酰酶 (HDAC) 抑制剂，对 HDAC10、HDAC1、HDAC2、 HDAC3 和 HDAC11 的 IC50 值分别为 0.32、0.353、0.431、0.515 和 85.4 μM。HDAC-IN-51 诱导细胞周期停滞和细胞凋亡，调节细胞周期/细胞凋亡相关的 miRNA 表达。HDAC-IN-51 可用于癌症研究。

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HDAC-IN-51

HDAC-IN-51 Chemical Structure

CAS No. : 3026728-28-6

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HDAC-IN-51 相关抗体

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-51 is a potent histone deacetylase (HDAC) inhibitor with IC50 values of 0.32, 0.353, 0.431, 0.515, and 85.4 μM for HDAC10, HDAC1, HDAC2, HDAC3 and HDAC11, respectively. HDAC-IN-51 induces cell cycle arrest and apoptosis, modulating cell cycle-/apoptosis-related miRNAs expression. HDAC-IN-51 can be used in research of cancer[1].

IC50 & Target[1]

HDAC10

0.32 μM (IC50)

HDAC1

0.353 μM (IC50)

HDAC2

0.431 μM (IC50)

HDAC3

0.515 μM (IC50)

HDAC11

85.4 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.51 μM
Compound: 8d; MC2666
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
HCT-116 IC50
0.32 μM
Compound: 8d; MC2666
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
K562 IC50
0.32 μM
Compound: 8d; MC2666
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 36549114]
体外研究
(In Vitro)

HDAC-IN-51 (compound 8d; 1 nM-10 μM; 48 h) has antiproliferative activity with IC50 values of 0.54, 0.56, and 1.35 μM for K562, HCT116, and A549 cells, respectively[1].
HDAC-IN-51 (1 and 5 μM; 24 and 48 h; U937 leukaemia cells) arrests cell cycle at the G1 phase[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) induces apoptosis and down-regulates miRNAs with antiapoptotic activity (miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p)[1].
HDAC-IN-51 (1 and 5 μM; 48 h; U937 cells) increases mRNA expression of p21, BAX and BAK, down-regulates cyclin D1 and BCL-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-51 相关抗体:

Cell Viability Assay[1]

Cell Line: K562, HCT116, and A549 cells
Concentration: 1 nM-10 μM
Incubation Time: 48 hours
Result: Inhibited cell growth in cancer cells.

Cell Cycle Analysis[1]

Cell Line: U937 leukaemia cells
Concentration: 1 and 5 μM
Incubation Time: 24 and 48 hours
Result: Blocked the cell cycle at the G1 phase in U937 leukaemia cells.

Western Blot Analysis[1]

Cell Line: U937 cells
Concentration: 1 and 5 μM
Incubation Time: 48 hours
Result: Down-regulates miRNAs with antiapoptotic activity including miR-17-5p, miR-18-5p, miR-19b-3p, miR-20a-5p,miR-21-5p.

Western Blot Analysis[1]

Cell Line: U937 cells
Concentration: 1 and 5 μM
Incubation Time: 48 hours
Result: Increased mRNA expression of p21, BAX and BAK and down-regulated cyclin D1 and BCL-2 in a dose-dependent manner.
分子量

436.51

Formula

C27H24N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-51 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-513026728-28-6HDACApoptosisBcl-2 FamilyCDKHistone deacetylasesCyclin dependent kinaseanticancercell cyclemiRNAsK562HCT116A549Inhibitorinhibitorinhibit

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