2. Cell Cycle/DNA Damage Epigenetics Immunology/Inflammation Apoptosis
  3. HDAC NOD-like Receptor (NLR) Interleukin Related Caspase
  4. HDAC3 degrader-1

HDAC3 degrader-1 (Compound Z8) 是一种选择性的 HDAC3 降解剂，其 DC50 为 2.42 μM。HDAC3 degrader-1 对 HDAC1、HDAC2 和 HDAC6 几乎无影响。HDAC3 degrader-1通过抑制 NLRP3 炎症小体活化，减少 IL-1β 和 caspase-1 的分泌。HDAC3 degrader-1 在脓毒症休克和结肠炎模型中展现出显著的疗效。HDAC3 degrader-1 可用于抗炎研究。

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HDAC3 degrader-1

HDAC3 degrader-1 Chemical Structure

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HDAC3 degrader-1 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC3 degrader-1 (Compound Z8) is a selective HDAC3 degrader with a DC50 of 2.42 μM. HDAC3 degrader-1 has almost no effect on HDAC1, HDAC2, and HDAC6. HDAC3 degrader-1 inhibits the activation of the NLRP3 inflammasome and reduces the secretion of IL-1β and caspase-1. HDAC3 degrader-1 shows significant efficacy in septic shock and colitis models. HDAC3 degrader-1 can be used in anti-inflammatory research[1].

IC50 & Target[1]

HDAC3

2.42 μM (DC50)

Caspase-1

 

IL-1β

 

NLRP3

 

分子量

578.78

Formula

C36H48F2N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC3 degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3 degrader-1HDACNOD-like Receptor (NLR)Interleukin RelatedCaspaseHistone deacetylasesILHDAC3DegradationAnti-inflammationNLRP3 inflammasomePROTACInflammatory bowel diseaseSepsisPharmacokineticsDrug designInhibitorinhibitorinhibit

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产品名称：
HDAC3 degrader-1
目录号：
HY-179682
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