2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. HDAC Apoptosis
  4. HDAC6-IN-22

HDAC6-IN-22 (compound 30) 是 HDAC6的抑制剂， IC50为 4.63 nM。HDAC6-IN-22 在体外和体内对多发性骨髓瘤具有抗增殖作用。HDAC6-IN-22 诱导细胞周期阻滞在 G2 期并通过线粒体途径促进细胞凋亡 (apoptosis)。

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HDAC6-IN-22

HDAC6-IN-22 Chemical Structure

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3.  试用装只面向终端客户。

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HDAC6-IN-22 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-22 (compound 30) is a inhibitor of HDAC6, with the IC50 of 4.63 nM. HDAC6-IN-22 has antiproliferative effects in vitro and in vivo towards multiple myeloma. HDAC6-IN-22 induces cell cycle arrest in the G2 phase and promotes apoptosis through the mitochondrial pathway[1].

IC50 & Target

4.63 nM (HDAC6)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCCLM3 IC50
> 50 μM
Compound: 29
Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HCCLM3 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
[PMID: 37797564]
HCT-116 IC50
5.521 μM
Compound: 29
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
[PMID: 37797564]
MDA-MB-468 IC50
43.99 μM
Compound: 29
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
[PMID: 37797564]
RPMI-8226 IC50
2.037 μM
Compound: 29
Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
[PMID: 37797564]
SGC-7901 IC50
40.85 μM
Compound: 29
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity against human SGC-7901 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
[PMID: 37797564]
分子量

400.47

Formula

C24H24N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-22HDACApoptosisHistone deacetylasesmultiple myelomaRPMI-8226cycle arrestapoptosisInhibitorinhibitorinhibit

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产品名称：
HDAC6-IN-22
目录号：
HY-156279
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