2. Apoptosis Epigenetics Cell Cycle/DNA Damage Cytoskeleton
  3. Apoptosis HDAC Microtubule/Tubulin
  4. HDAC6-IN-73

HDAC6-IN-73 是一种高效且选择性的 HDAC6 抑制剂 (IC50=7 nM)，对 HDAC1 的选择性约为 1771 倍 (IC50=12.4 μM)，对 HDAC8 的选择性约为 131 倍 (IC50=0.92 μM)。HDAC6-IN-73 对血液癌细胞系中具有抗增殖活性。HDAC6-IN-73 可用于血液系统恶性肿瘤的研究。

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HDAC6-IN-73

HDAC6-IN-73 Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

HDAC6-IN-73 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-73 is a highly potent and selective HDAC6 inhibitor with an IC50 of 0.007 μM ± 0.001, ~1771-fold selectivity over HDAC1, ~131-fold selectivity over HDAC8, and antiproliferative activity in hematological cancer cell lines.HDAC6-IN-73 can be used for the research of hematological malignancies[1].

IC50 & Target

HDAC6

7 nM (IC50)

HDAC1

12.4 μM (IC50)

HDAC8

0.92 μM (IC50)

体外研究
(In Vitro)

HDAC6-IN-73 (compound 7c) 显著抑制 Jurkat，Namalwa，和 K-562 细胞的增殖[1].
HDAC6-IN-73 对血液癌细胞系具有微摩尔级别的细胞毒性，且相较于部分正常细胞，对恶性细胞的活性更强[1]。
HDAC6-IN-73 (50 μM; 48 h) 在 Namalwa 细胞中诱导了显著的晚期和早期凋亡，并使 Namalwa 细胞在亚 G1 期积累；在 Jurkat 或K-562 细胞中未观察到明显的细胞周期变化[1]。
HDAC6-IN-73 (50 μM; 24 h) 在 Jurkat 和 Namalwa 细胞中诱导 α-微管蛋白显著乙酰化，对组蛋白 H3 乙酰化的影响极小；在 K-562 细胞中未检测到 α-微管蛋白乙酰化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-73 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: Jurkat, Namalwa, and K-562 cells; HS-5, CCD-18Co, HaCaT cells
Concentration: IC50 assay
Incubation Time: 72 h
Result: Exhibited the strongest antiproliferative effects against Jurkat, Namalwa, and K-562 cells with IC50 of 3.7 μM, 7.7 μM, 18 μM; as well as inhibiting HS-5, CCD-18Co, HaCaT cells with 9.3 μM, 33 μM, and 10.3 μM.

Apoptosis Analysis[1]

Cell Line: Jurkat, Namalwa, and K-562 cells
Concentration: 50 μM
Incubation Time: 48 h
Result: Induced significant late and early apoptosis in Namalwa cells, with apoptosis rates at 50 μM exceeding those of reference compounds.
Promoted accumulation of cells in the sub-G1 phase in Namalwa cells; showed no significant cell cycle changes in Jurkat or K-562 cells.

Western Blot Analysis[1]

Cell Line: Jurkat, Namalwa, and K-562 cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Induced marked acetylation of α-tubulin with minimal effect on histone H3 acetylation in Jurkat and Namalwa cells; showed no detectable α-tubulin acetylation in K-562 cells.
分子量

412.48

Formula

C23H28N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-73 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-73ApoptosisHDACMicrotubule/TubulinHistone deacetylasesHDAC6hematological malignanciesnormal cell typesHDAC8HDAC1hematological cancer cell linesInhibitorinhibitorinhibit

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