2. MAPK/ERK Pathway
  3. p38 MAPK JNK
  4. HE4-1 leech peptide

HE4-1 leech peptide 是一种 p38 MAPK 抑制剂，同时还具有 c-Jun N-terminal kinase (JNK) 抑制作用。HE4-1 leech peptide 可抑制巨噬细胞迁移，且对巨噬细胞的吞噬能力、溶菌酶活性以及多数炎症因子的表达水平等免疫活性无显著影响。HE4-1 leech peptide 可用于动脉粥样硬化的研究。

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HE4-1 leech peptide

HE4-1 leech peptide Chemical Structure

CAS No. : 2531396-44-6

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HE4-1 leech peptide 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HE4-1 leech peptide is a p38 MAPK inhibitor with an additional c-Jun N-terminal kinase (JNK) inhibitory role. HE4-1 leech peptide suppresses macrophage migration, and does not significantly affect macrophage immunological activities including phagocytic ability, lysozyme activity, and expression levels of most inflammatory factors. HE4-1 leech peptide can be used for the research of atherosclerosis[1].

体外研究
(In Vitro)

HE4-1 leech peptide (200-800 μg/mL；LPS 预处理 2 小时后作用 24 小时) 可通过 p38 MAPK 和 JNK 信号通路抑制 LPS 诱导的 RAW264.7 巨噬细胞迁移，并下调 MEKK4 和 ASK2 的转录[1]。
HE4-1 leech peptide (200-800 μg/mL；LPS 预处理 2 小时后作用 24 小时) 在最高达 800 μg/mL 的浓度下，对 RAW264.7 巨噬细胞的吞噬能力、溶菌酶活性以及 IL-1β、IL-6 或 IL-12 的分泌均无显著影响，但在 400 μg/mL 和 800 μg/mL 浓度下会促进 TNF-α 的分泌[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HE4-1 leech peptide 相关抗体:

Cell Migration Assay[1]

Cell Line: RAW264.7 cells
Concentration: 200-800 μg/mL
Incubation Time: 24 h (after 2 h LPS pretreatment)
Result: Inhibited LPS-induced migration of RAW264.7 cells; reduced LPS-induced macrophage migration by 15.2% at 800 μg/mL.\nInhibited LPS-induced migration of RAW264.7 macrophages by 14.9% at 800 μg/mL, similar to the effect of HE4-1.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 200-800 μg/mL
Incubation Time: 24 h (after 2 h LPS pretreatment)
Result: Did not alter total JNK or p38 protein levels; significantly inhibited LPS-induced phosphorylation of JNK and p38 at 800 μg/mL.
分子量

1429.49

Formula

C59H96N16O25
CAS 号
Sequence

Glu-Ala-Gly-Ser-Ala-Lys-Glu-Leu-Glu-Gly-Asp-Pro-Val-Ala-Gly
Sequence Shortening

EAGSAKELEGDPVAG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HE4-1 leech peptide 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HE4-1 leech peptide2531396-44-6p38 MAPKJNKc-Jun N-terminal kinaseLPSMEKK4atherosclerosisp38 mitogen-activated protein kinaseASK2RAW264.7 macrophagesmacrophagesIL-1βIL-6Inhibitorinhibitorinhibit

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