2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage Epigenetics
  3. EGFR PARP
  4. HER2-IN-23

HER2-IN-23 是一种选择性 HER2 抑制剂。HER2-IN-23 降低的是总 HER2 表达，而非磷酸化 HER2 (p-HER2) 的表达。HER2-IN-23 可降低细胞周期蛋白 D1 水平并刺激 PARP 裂解。HER2-IN-23 可用于 HER2 阳性乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

HER2-IN-23

HER2-IN-23 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

HER2-IN-23 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HER2-IN-23 is a selective HER2 inhibitor. HER2-IN-23 reduces in total HER2 expression rather than in phosphorylated HER2 (p-HER2). HER2-IN-23 reduces cyclin D1 level and stimulates PARP cleavage. HER2-IN-23 can be used for the study of HER2-positive breast cancer[1].

体外研究
(In Vitro)

HER2-IN-23 (Compound 4o) (0.4-25 μM，72 小时) 对 HER2 阳性细胞 (如 BT474 (IC50 = 10.5 μM)、A431 (IC50 = 9.9 μM) 和 HCC1954 (IC50 = 8.5 μM)) 表现出中等的抗增殖活性，但对 HER2 阴性细胞 (如 MDA-MB-231 (IC50 = 19.7 μM) 和 MCF7 (IC50 = 12.8 μM)) 的活性较低[1]。
HER2-IN-23 (1 μM) 在 1 μM 浓度下可抑制 HER2 激酶 84%，而对其他激酶 (如 EGFR、HER4、IGF1R 等) 的抑制作用较弱或无抑制作用[1]。
HER2-IN-23 (10 μM, 24 h) 显著降低了 A431 细胞中总 HER2 的表达，但磷酸化 HER2 (p-HER2) 没有显著变化；同时，细胞周期蛋白 D1 的表达几乎完全受到抑制，并且观察到 PARP 裂解增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HER2-IN-23 相关抗体:

Western Blot Analysis[1]

Cell Line: A431 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Significantly reduced total HER2 expression in A431 cells, but phosphorylated HER2 (p-HER2) showed no significant change; simultaneously, cyclin D1 expression was almost completely inhibited, and an increase in PARP cleavage was observed.
分子量

398.81

Formula

C22H16ClFO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HER2-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HER2-IN-23EGFRPARPEpidermal growth factor receptorErbB-1HER1poly ADP ribose polymeraseIsoflavones7,8-dihydro-4H-chromene-4,5(6H)-dionesHER2 Antiproliferative activityTyrosine kinasesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HER2-IN-23
目录号：
HY-178116
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z