2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. Histamine glutarimide

Histamine glutarimide (XC8) 是一种口服有效的抗哮喘剂。Histamine glutarimide 阻断趋化因子 (CCL2、CCL7、CCL8、CCL13) 的成熟，抑制嗜酸性粒细胞迁移和肥大细胞脱颗粒。Histamine glutarimide 在角叉菜胶和大鼠卵清蛋白诱导的哮喘模型中能降低气道阻力和支气管肺泡灌洗液中的嗜酸性粒细胞计数。Histamine glutarimide 可用于哮喘研究。

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Histamine glutarimide

Histamine glutarimide Chemical Structure

CAS No. : 1464897-15-1

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Histamine glutarimide 相关抗体

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生物活性

Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research[1].

分子量

207.23

Formula

C10H13N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Histamine glutarimide 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Histamine glutarimide1464897-15-1XC8XC 8XC-8CCRCC chemokine receptorPhase 1 clinical trialhistamine glutarimideasthma treatmentpharmacokineticssafety profiledose proportionalityhealthy volunteersoral anti-asthmatic agentInhibitorinhibitorinhibit

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