2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. HM12

HM12 是一种 L 型/T 型钙通道 (L-/T-type calcium channel) 的共价抑制剂。HM12 能强效抑制 Cav1.2 (L 型) 和 Cav3.2 (T 型) 钙通道，并且对 N 型通道具有选择性。HM12 产生的抑制作用是不可逆的，即使洗脱后抑制作用仍然存在。HM12 可用于研究高血压、疼痛、癫痫等疾病。

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HM12

HM12 Chemical Structure

CAS No. : 2376051-91-9

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HM12 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc[1].

IC50 & Target[1]

Cav1.2

 

Cav3.2

 

体外研究
(In Vitro)

HM12 (10 μM) 对 Cav3.2 钙通道表现出 > 90% 的抑制活性，对 Cav1.2 钙通道表现出 > 60% 的抑制活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HM12 相关抗体:
分子量

597.29

Formula

C25H27Br2NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HM12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HM122376051-91-9HM 12HM-12Calcium ChannelCa2+ channelsCa channelsDihydropyridineHexahydroquinolineCalcium channel blockerWhole-cell patch clampCovalent bindingMolecular modelingInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-126336
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