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  4. Homidium chloride

Homidium chloride 是一种强效抗寄生虫 (antiparasitic) 剂，对非洲锥虫 (Trypanosoma rhodesiense) 和刚果锥虫 (Trypanosoma congolense) 具有活性。Homidium chloride 可降低小鼠感染模型中的寄生虫负荷。Homidium chloride 可用于锥虫病的相关研究。

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Homidium chloride

Homidium chloride Chemical Structure

CAS No. : 602-52-8

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Homidium chloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Homidium chloride is a potent antiparasitic agent exhibiting activity against Trypanosoma rhodesiense and Trypanosoma congolense. Homidium chloride can reduce parasitaemia in murine models of infection. Homidium chloride can be used for trypanosomiasis research[1][2].

体外研究
(In Vitro)

Homidium chloride (0.001-10 μg/mL；6 小时) 在柠檬酸盐-生理盐水中，当浓度 ≥ 0.1 μg/mL 时可消除刚果锥虫的感染性；但在马血清中无效 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Homidium chloride 相关抗体:
体内研究
(In Vivo)

Homidium (0.075-75.0 mg/kg；i.p.，单次给药) chloride 在感染抑制小鼠模型中对 T. rhodesiense 和 T. congolense 表现出抗锥虫活性，对 T. rhodesiense 的活性更强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice infected with T. rhodesiense and T. congolense[1]
Dosage: 75.0, 7.5, 0.75, 0.075 mg/kg
Administration: i.p.; single dose
Result: Exhibited antitrypanosomal activity against both T. rhodesiense and T. congolense.
Was approximately 12.5 times more active against T. congolense compared to T. rhodesiense.
分子量

349.86

Formula

C21H20ClN3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Homidium chloride 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homidium602-52-8ParasitetrypanosomiasisTrypanosoma congolenseTrypanosoma rhodesienselivestocktrypanosome inhibitorgoatstrypanosome infectionscalvesphenanthridinium trypanocidemiceInhibitorinhibitorinhibit

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