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  4. Hydrangeic acid

Hydrangeic acid 是一种口服有效的降血糖、降血脂的二苯乙烯类糖脂代谢调节剂，能够从绣球花 (Hydrangea macrophylla var. thunbergii) 加工叶中分离得到。Hydrangeic acid 与糖脂代谢及胰岛素敏感性调控相关。Hydrangeic acid 不直接激活 PPARγ 或 PPARα ，而是上调脂联素、PPARγ2、GLUT4、脂肪酸结合蛋白 aP2 的 mRNA 表达，下调 TNF-α mRNA 表达，促进 3T3-L1 细胞成脂、葡萄糖摄取及 GLUT4 转运。同时，Hydrangeic acid 抑制炎症因子诱导的 NO 产生，发挥改善胰岛素抵抗的活性。Hydrangeic acid 可用于 2 型糖尿病的相关研究，无肝脏增重副作用。

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Hydrangeic acid

Hydrangeic acid Chemical Structure

CAS No. : 491-79-2

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Hydrangeic acid 相关抗体

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生物活性

Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. It can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. Hydrangeic acid is associated with glycolipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα, but instead upregulates the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2, and downregulates TNF-α mRNA expression, promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Simultaneously, Hydrangeic acid inhibits inflammatory factor-induced NO production, exerting activity in improving insulin resistance. Hydrangeic acid can be used in research related to type 2 diabetes and does not cause liver weight gain as a side effect.

IC50 & Target

PPARγ2

 

GLUT4

 

分子量

256.25

Formula

C15H12O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Hydrangeic acid 相关分类

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Keywords:

Hydrangeic acid491-79-2PPARGLUTTNF ReceptorPeroxisome proliferator-activated receptorsGlucose transporter Tumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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