2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. IAG-10

IAG-10 是一种选择性 DNA 聚合酶 kappa (hpol κ) 抑制剂，IC50 值为 7.2 μM。IAG-10 通过破坏酶与 DNA 的二元复合物形成发挥作用。IAG-10 可在 hpol κ 功能性表达肿瘤细胞中增强 Temozolomide (HY-17364) 的抗增殖和 DNA 损伤活性。IAG-10 可用于恶性脑肿瘤等癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

IAG-10

IAG-10 Chemical Structure

CAS No. : 2361305-69-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

IAG-10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors[1].

体外研究
(In Vitro)

IAG-10 (0.1-0.5 μM；1 小时) 可增强 Temozolomide (HY-17364) 在 hpol κ 功能正常的 HAP-1 细胞中的抗增殖作用，但在 hpol κ 缺陷型细胞中无此作用，提示其具有靶点依赖性活性[1]。
IAG-10 (0.5 μM；1 小时) 可单独或与 Temozolomide (HY-17364) 联合增加 hpol κ 功能正常的 HAP-1 细胞的 DNA 损伤，但对 hpol κ 功能缺陷的细胞无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IAG-10 相关抗体:

Cell Proliferation Assay[1]

Cell Line: hpol κ-proficient (HAP-1), hpol κ-deficient (HAP-1 hpol κ KO) cells
Concentration: 0.1 μM, 0.5 μM
Incubation Time: 1 hour
Result: Reduced colony formation by hpol κ-proficient cells at all TMZ concentrations tested when co-treated with 0.5 μM IAG-10 compared to TMZ alone.
Reduced colony formation to ~40% of untreated cells at 250 μM TMZ + 0.5 μM IAG-10, while TMZ alone allowed ~75% colony formation.
Caused no significant reduction in hpol κ-deficient cells.
分子量

426.30

Formula

C21H17Cl2N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IAG-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IAG-102361305-69-1IAG10IAG 10DNA/RNA Synthesishpol κglioblastomaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
IAG-10
目录号：
HY-180392
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z