2. Immunology/Inflammation
  3. CD19
  4. IASO-782

IASO-782 (RD126) 是一种靶向人 CD19 的全人源单克隆抗体。IASO-782 的 Fc 片段经过突变，可增强抗体依赖性细胞介导的细胞毒性 (ADCC)，同时保持其他 Fc 片段功能 (例如 ADCP) 的完整性。IASO-782 可有效清除 CD19+ B 细胞、浆母细胞和部分浆细胞，从而减少或完全清除这些细胞产生的自身反应性抗体。IASO-782 可用于免疫性血小板减少性紫癜 (ITP)、温型自身免疫性溶血性贫血 (wAIHA) 和系统性红斑狼疮 (SLE) 的研究。

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IASO-782

IASO-782 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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IASO-782 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

IASO-782 (RD126) is a fully human monoclonal antibody targeting human CD19. The Fc segment of IASO-782 is mutated to enhance antibody-dependent cell-mediated cytotoxicity (ADCC) while maintaining the integrity of other Fc segment functions, such as ADCP. IASO-782 effectively eliminates CD19+ B cells, plasmablasts, and some plasma cells, thereby reducing or completely eliminating autoreactive antibodies produced by these cells. IASO-782 can be used for the study of immune thrombocytopenic purpura (ITP), warm autoimmune hemolytic anemia (wAIHA) and systemic lupus erythematosus (SLE).

反应种属

Human
IC50 & Target

CD19
基因 ID

930  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

IASO-782 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IASO-782RD126IASO782IASO 782RD 126RD-126CD19Anti-CD19 antibodyantibody-dependent cell-mediated cytotoxicity (ADCC) CD19+ B cellsimmune thrombocytopenic purpura (ITP)warm autoimmune hemolytic anemia (wAIHA) and systemic lupus erythematosus (SLE)Inhibitorinhibitorinhibit

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产品名称：
IASO-782
目录号：
HY-P991898
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