2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Interleukin Related STAT IFNAR
  4. Icotrokinra acetate

Icotrokinra acetate  (Synonyms: JNJ-77242113 acetate; JNJ-2113 acetate; PN-235 acetate)

目录号: HY-P10587A
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Icotrokinra (JNJ-77242113) acetate 是一种口服有效的 IL-23 受体 (IL-23 receptor) 选择性拮抗剂。Icotrokinra 可抑制外周血单核细胞 (PMBC) 中 IL-23 诱导的 STAT3 磷酸化 (IC50=5.6 pM)，并抑制 NK 细胞中 IL-23 诱导的干扰素 IFN-γ 的产生，IC50 为 18.4 pM。Icotrokinra acetate 在 TNBS 诱导的大鼠结肠炎模型中表现出抗炎活性。Icotrokinra acetate 可用于银屑病、银屑病关节炎和炎症性肠病的研究。

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Custom Peptide Synthesis

Icotrokinra acetate

Icotrokinra acetate Chemical Structure

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Icotrokinra acetate 的其他形式现货产品:

Customer Review

Other Forms of Icotrokinra acetate:

Icotrokinra acetate 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Icotrokinra (JNJ-77242113) acetate is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra acetate inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra acetate exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra acetate can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease[1].

IC50 & Target[1]

IL-23

7.1 pM (Kd)

体内研究
(In Vivo)

Icotrokinra (0.03-10 mg/kg; p.o.; 每天 1 次持续 7 天) acetate 降低了 TNBS 诱导的结肠炎大鼠的结肠重长比并缓解 TNBS 诱导的结肠炎大鼠体重减轻[1]。
Icotrokinra (1-30 mg/kg; p.o; 每天 2 次持续 3 天) acetate 在大鼠皮肤炎症模型中当剂量大于 10 mg/kg 时，阻止 IL-23 诱导的 IL-17A 和 IL-22 的上调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1898.17 (free base)

Formula

C90H120N20O22S2·xC2H4O2
性状

固体

颜色

White to off-white

Sequence

Ac-Pen-Asn-Thr-Trp(7-Me)-Lys(Ac)-Pen-Phe(4-amino ethoxy)-2Nal-ThpGly-Glu-Asn-3Pal-Sar-NH2 (Pen1&Pen6 bridge)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Icotrokinra acetate 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IcotrokinraJNJ-77242113JNJ-2113PN-235JNJ77242113JNJ 77242113JNJ2113JNJ 2113PN235PN 235Interleukin RelatedSTATIFNARILInterferon-α/β receptorInterferon-alpha/beta receptorPMBCpsoriasiscolitisSprague-Dawley ratinflammatory bowel diseaseorally activeInhibitorinhibitorinhibit

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