2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Drug Derivative Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. Idebenone-SS-20

Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) 是 Idebenone (HY-N0303) 的衍生物，与线粒体靶向肽 SS-20 偶联。Idebenone-SS-20 具有神经保护和抗炎作用。Idebenone-SS-20 可维持线粒体膜电位、促进 ATP 生成、减少活性氧 (ROS) 蓄积、维持线粒体形态、提高 NAD+/NADH 比值。Idebenone-SS-20 在短暂性大脑中动脉闭塞小鼠模型中表现出强效神经保护作用。Idebenone-SS-20 可用于脑缺血再灌注损伤的相关研究。

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Idebenone-SS-20

Idebenone-SS-20 Chemical Structure

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Idebenone-SS-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a Idebenone (HY-N0303) derivative conjugated to the mitochondria-targeting peptide SS-20. Idebenone-SS-20 shows neuroprotective and anti-inflammatory effects. Idebenone-SS-20 can preserve mitochondrial membrane potential, enhance ATP production, reduce ROS accumulation, maintain mitochondrial morphology and elevate NAD+/NADH ratio. Idebenone-SS-20 confers robust neuroprotection in a murine model of transient middle cerebral artery occlusion. Idebenone-SS-20 can be used for the research of cerebral[1].

体外研究
(In Vitro)

Idebenone-SS-20 (Compound W1a) (0.625-5 μM；24 h) 可保护 HT22 海马神经元细胞免受谷氨酸诱导的损伤，其 EC50 为 0.713 μM，且细胞毒性的 IC50 为 68.4 μM[1]。
Idebenone-SS-20 (5 μM；12 h) 在谷氨酸损伤的 HT22 海马神经元细胞中恢复 ATP 生成，保护线粒体形态，减少超氧阴离子生成并恢复膜电位，效果优于 Idebenone (HY-N0303)[1]。
Idebenone-SS-20 (10 μM；24 h) 可抑制 LPS (HY-D1056) 诱导的 BV2 小胶质细胞炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Idebenone-SS-20 相关抗体:

Real Time qPCR[1]

Cell Line: BV2 microglial cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Significantly inhibited LPS-induced upregulation of Il6, Tnf, and Il1b mRNA levels (with greater efficacy than idebenone) and preserved mitochondrial length and morphology.
体内研究
(In Vivo)

Idebenone-SS-20 (Compound W1a) (20 mg/kg；腹腔注射；2 次，分别于术后即刻及再灌注起始时给药) 在 C57BL/6J 小鼠中展现出更优异的脑缺血再灌注损伤神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (male, 8-10 weeks, 22 ± 2 g, transient middle cerebral artery occlusion)[1]
Dosage: 20 mg/kg
Administration: I.p.; twice (immediately after surgery and at reperfusion onset)
Result: Significantly reduced cerebral infarct volume and suppressed neuronal death.
Increased 7-day survival rate and improved neurological recovery as measured by higher Garcia scores and longer rotarod latencies.
Restored mitochondrial gene expression (mitochondrial respiratory chain complex I assembly, electron transport chain activity, proton-driven ATP synthesis pathways).
Elevated NAD+/NADH ratio and ATP levels in brain tissue and reduced ROS accumulation.
Attenuated mitochondrial structural damage (swelling, cristae disintegration) and suppressed pro-inflammatory pathways (IL-17, NF-κB, TNF signaling) and glial (microglial, astrocytic) activation.
分子量

1108.42

Formula

C55H81N9O11S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Idebenone-SS-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idebenone-SS-20Idebenone-2S-FrFK-NH2Drug DerivativeReactive Oxygen Species (ROS)Mitochondrial MetabolismDrug derivativeglutamateHT22BV2C57BL/6JIL-17NF-κBTNFInhibitorinhibitorinhibit

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