2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO) Cytochrome P450
  4. IDO1-IN-30

IDO1-IN-30 (Compound (R)-100) 是一种强效、高选择性的 IDO1 抑制剂。IDO1-IN-30 在 SKOV3 细胞中对 IDO1 的 IC50 为4.8 nM。IDO1-IN-30 在 HepG2 细胞中，25 µM 时没有显示出明显的细胞毒性。IDO1-IN-30 可以消除对 CYP450 酶 (如 3A4，2C9，2D6) 的抑制。IDO1-IN-30 可以用于癌症和炎症性疾病的研究。

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IDO1-IN-30

IDO1-IN-30 Chemical Structure

CAS No. : 2581050-29-3

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IDO1-IN-30 相关抗体

Top Publications Citing Use of Products

查看 Indoleamine 2,3-Dioxygenase (IDO) 亚型特异性产品:

查看所有亚型
IDO1 IDO2 IDO

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1-IN-30 (Compound (R)-100) is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC50 of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions[1].

分子量

398.37

Formula

C19H16F2N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IDO1-IN-30 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDO1-IN-302581050-29-3Indoleamine 2,3-Dioxygenase (IDO)Cytochrome P450CYPsIDO1SKOV3HepG2CYP450cancerinflammationInhibitorinhibitorinhibit

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