2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Phosphoglycerate Kinase (PGK) Fungal Apoptosis
  4. Ilicicolin H

Ilicicolin H 是一种选择性且非 ATP 竞争性的磷酸甘油酸激酶 1 (PGK1) (IC50 值为 9.02 μM) 和线粒体细胞色素 bc1 还原酶 (IC50 值为 2-3 ng/mL) 抑制剂。Ilicicolin H 直接与 PGK1 结合，KD 值为 60 μM。Ilicicolin H 能够抑制细胞增殖并诱导细胞凋亡 (apoptosis)。Ilicicolin H 可以抑制肝癌细胞的乳酸生成和葡萄糖摄取。Ilicicolin H 具有广泛的抗真菌谱，包括白色念珠菌 (C. albicans)、隐球菌属 (Cryptococcus) 和烟曲霉菌 (A. fumigatus)。licicolin H 可用于癌症和感染方面的研究，如肝细胞癌 (HCC) 和白色念珠菌感染。

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Ilicicolin H

Ilicicolin H Chemical Structure

CAS No. : 12689-26-8

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Ilicicolin H 相关抗体

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查看 Phosphoglycerate Kinase (PGK) 亚型特异性产品:

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PGK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2].

IC50 & Target[1]

PGK1

9.02 μM (IC50)

体外研究
(In Vitro)

Ilicicolin H (1-8 μM, 24 h) 会诱导 HepG2 和 Huh7 细胞凋亡，并增加 Caspase-3、Caspase-9 的活性切割片段水平[1]。
Ilicicolin H (2-8 μM, 6 h) 会降低 CoCl 2 诱导的 HepG2 细胞中 HIF-1α 的水平，以及表皮生长因子诱导的该细胞中 PDHK1 在 T338 位点的磷酸化水平[1]。
Ilicicolin H (1-8 μM, 6 h) 会抑制 HepG2 细胞的乳酸生成和葡萄糖摄取[1]。
Ilicicolin H 对白色念珠菌 (C. albicans) 活性范围为 0.04 至 0.31 μg/mL、其他念珠菌属物种为 0.01 至 5.0 μg/mL、隐球菌属 (Cryptococcus) 的 MIC 值为 0.1-1.56 μg/mL，烟曲霉 (A. fumigatus) 的 MIC 值为 0.08 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ilicicolin H 相关抗体:

Apoptosis Analysis[1]

Cell Line: HepG2 and Huh7 cells
Concentration: 1, 2, 4 and 8 μM
Incubation Time: 24 h
Result: Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.
体内研究
(In Vivo)

Ilicicolin H (6.25-50 mg/kg，口服，每日一次，连续 2 天) 可降低白色念珠菌 (C. albicans) 感染的小鼠模型中的白色念珠菌负荷量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. albicans infected mice models[2]
Dosage: 6.25, 12.5, 25 and 50 mg/kg
Administration: Orally administration, daily for 2 days
Result: Reduced C. albicans burden.
分子量

433.54

Formula

C27H31NO4
CAS 号
结构分类
初始来源

Campylocarpon sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ilicicolin H 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilicicolin H12689-26-8Phosphoglycerate Kinase (PGK)FungalApoptosisPhosphoglycerate KinasePGK1Bc1C. albicansCryptococcusHepG2Huh7Inhibitorinhibitorinhibit

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