2. 寡核苷酸
  3. 反义寡核苷酸
  4. Inactive ASO (in vivo) sodium

Inactive ASO (in vivo) sodium 

目录号: HY-153734 纯度: 92.18%
COA 产品使用指南 技术支持

Inactive ASO (in vivo) sodium 是一种未激活的反义寡核苷酸 (Antisense Oligonucleotide)。Inactive ASO (in vivo) sodium 在啮齿类动物基因组中无靶向性，可作为 Tofersen 的阴性对照。Inactive ASO (in vivo) sodium 含有硫代磷酸骨架修饰 和 MOE 修饰。Inactive ASO (in vivo) sodium 的胞嘧啶均为 5'甲基胞嘧啶。化学修饰的位置见参考文献。

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病毒包装服务

CCTATAGGACTATCCAGGAA

Inactive ASO (in vivo) sodium Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥970
In-stock
5 mg ￥2200
In-stock
10 mg ￥3820
In-stock
25 mg 现货 询价
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Inactive ASO (in vivo) sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Inactive ASO (in vivo) sodium is an inactive Antisense Oligonucleotide. ASO is a class of oligonucleotide molecules, usually composed of 20-30 bases, used to interfere with or regulate gene expression. Inactive ASO (in vivo) sodium is not targeted in the rodent genome and can be used as a negative control for Tofersen. Inactive ASO (in vivo) sodium contains thiophosphate skeleton modification and MOE modification. Cytosine in Inactive ASO (in vivo) is 5' methylcytosine. See References for the location of chemical modifications

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 92.18%

COA (279 KB) LCMS (307 KB)

产品使用指南 (1538 KB)
参考文献

Inactive ASO (in vivo) sodium 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inactive ASO (in vivo)OthersInhibitorinhibitorinhibit

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} var input = $(drag).find("input"); var elemCancel = $(touch.target).closest(input).is(":focus"); if (elemCancel) { flag = false; } $("body,html").css({"user-select":"none"}); } function mouseUp(){ this.onmousemove=null; this.onmouseup=null; this.ontouchmove=null; this.ontouchend=null; if (drag.releaseCapture) { drag.releaseCapture(); } $("body,html").css({"user-select":"auto"}); } return false; } function dragMoves(drag) { drag.addEventListener("mousedown",function(ev){ downMove(drag, ev); }); drag.addEventListener("touchstart",function(ev){ downMove(drag, ev); }) } var dragGeneral = document.querySelector("#loginProGeneral"); var dragLogin = document.querySelector("#loginProLogin"); dragMoves(dragGeneral); dragMoves(dragLogin); }); // var initStopn = 0; // var targetTop = 537; // var targetTopDiv = 0; // var loginDivheight = 430; // isCnProdetail = true; // $('html,body').animate({scrollTop:0},1000); //$(".zhuce").offset().top; // function prodetailLogin() { // var stopn = $(window).scrollTop(); // var stopn2 = $(window).scrollTop() - initStopn; // var promise = $("#main_nav").offset().top; // var winheight= ($(window).height()); // var promisepro = 716; // // // // if (stopn >= promise) { // $('.pro_mask').css("top","88px"); // } // else { // $('.pro_mask').css("top","120px"); // } // // if (winheight < promisepro) { // if (stopn2 > 0) { // if (targetTop > 368) { // targetTop = targetTop - stopn2 <= 368 ? 368 : targetTop - stopn2; // } // } // } else { // if (stopn2 < 0) { // targetTop = targetTop - stopn2 >= 537 ? 537 : targetTop - stopn2; // } // loginDivheight = 430; // $('.pro_login').removeClass('divlogoverflow'); // } // // if (targetTop <= 368) { // let h1 = 650 - winheight; // let new_loginDivheight = h1 >= 0 ? 430 - h1 : 430 ; // $('.pro_login').height(new_loginDivheight); // let c_h = loginDivheight - new_loginDivheight; // targetTop = targetTop - c_h / 2; // loginDivheight = new_loginDivheight; // if (new_loginDivheight < 430) { // $('.pro_login').addClass('divlogoverflow'); // } else { // $('.pro_login').removeClass('divlogoverflow'); // } // // } // // $('.pro_login').css("top", targetTop + "px"); // initStopn = $(window).scrollTop(); // } var sel_array = $('[name="pro_cart_mg_num"]'); var mg_array = $('[name="pro_cart_mg"]'); var dw_sel_array = $('[name="pro_cart_dw_num"]'); var dw_array = $('[name="pro_cart_dw"]'); var eta_showStockType = "1"; var eta_infringementType = "0"; function updateProETA(){ var isChange = false; var isPrepare = false; var isETA = false; // var sel_num = $(currentE).val(); // if (parseInt(sh_stock_num) < parseInt(sel_num)) { // $('#pro_detail_eta').show(); // $('#pro_detail_eta').html(getEtaCnMessage()); // } else { // $('#pro_detail_eta').hide(); // $('#pro_detail_eta').html(""); // } var delivery = ''; dw_sel_array.each(function(index,domEle) { var option_dw = $(dw_array.eq(index)).val().split(";"); var dw_sh_stock_num = option_dw[6]; var dw_us_stock_num = option_dw[7]; var dw_select_num = $(domEle).val(); if (parseInt(dw_sh_stock_num) < parseInt(dw_select_num)) { isETA = true; if (dw_us_stock_num == 9527) { isChange = true; } if (dw_us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); //alert('isDW:'+isDW); sel_array.each(function(index,domEle){ var select_num = $(domEle).val(); var option_mg = $(mg_array.eq(index)).val().split(";"); var sh_stock_num = option_mg[6]; var us_stock_num = option_mg[7]; var eta_message = ''; if (parseInt(sh_stock_num) < parseInt(select_num)) { isETA = true; if (us_stock_num == 9527) { isChange = true; } if (us_stock_num == 99999) { isPrepare = true; } delivery = $(domEle).closest('tr').find('.pro_price_3').text() return false; } }); // 20200519 wdf if (isETA == true) { if (isPrepare || isChange) { $('#pro_detail_eta').html("预计 " + delivery + " 发货"); } else { var catNo = "HY-153734"; changeCnEtaMessage(isChange); //$('#pro_detail_eta').show(); $('#pro_detail_eta').html(getEtaCnMessage(catNo, isChange)); } } else { //$('#pro_detail_eta').hide(); $('#pro_detail_eta').html(""); } } function qtyChange(){ updateProETA(); } // Product Isoform by WDF 20180508 $(function () { fnSetIC50Style(); fnIsoformWidth(); proRelatedImgCN(); //normalSalineDisplacement(); }); // Isoform width function fnIsoformWidth(){ var isoformProList = $(".isoform-pro-list"); var isoformProListLen = isoformProList.length; for(var i = 0; i < isoformProListLen; i++){ var isoformProSpan = isoformProList.eq(i).find("span"); var isoformProSpanLen = isoformProSpan.length; if(isoformProSpanLen>4) { isoformProSpan.parent().css({"width":"100%"}); isoformProSpan.css({"width":"auto"}); } else { isoformProSpan.parent().css({"width":(isoformProSpanLen/4*100)+"%" }); isoformProSpan.css({"width":(1/isoformProSpanLen*100)+"%" }); } } } /* * Target&IC50 Table => 原理 * 1. 计算每个格子的宽度，如果格子的总宽度 <= iContainerW(固定行宽)，则一行显示; 否则多行显示 * 2. 多行的情况: 列数 = iContainerW/最宽单元格的列宽(取整); 列宽 = iContainerW/列数 * 3. 如果一行中, IC50值全是空，那么这一行 IC50 全隐藏，Isoform 垂直居中对齐 */ function fnSetIC50Style(){ var oContainer = $("#pro-ic50-tbl"); var iContainerW = 827; var spanLen = oContainer.find("span").length; var tdLen = spanLen/2; // 单元格总数 var spanArr = []; var spanTotalW = 0; var spanwMax = 0; // span 相加总长度 var lastW = 0; if(tdLen > 1){ for(var i = 0; i < tdLen; i++){ var spanW = [oContainer.find("td").eq(i).find("span").eq(0).outerWidth(),oContainer.find("td").eq(i).find("span").eq(1).outerWidth()].max(); spanArr.push(spanW); spanTotalW += spanW; if(i==tdLen-1){ lastW = oContainer.find("td").eq(i).find("span").eq(0).outerWidth(); } } } spanwMax = spanArr.max(); // console.log("spanwMax= " + spanwMax); // console.log("spanArr=" +spanArr); // 如果 spanwMax > iContainerW 分行; 否则, 一行显示 if(spanTotalW <= iContainerW){ oContainer.find("td").addClass("ic50-td0"); oContainer.find("td:last-child").css({"width": (iContainerW-lastW)+"px"}); // 最后一列宽度 oContainer.find(".ic50-td0").wrapAll(""); }else { var trtdNum = parseInt(iContainerW / spanwMax); // 每一行的列数 var tdWidth = iContainerW/trtdNum; //列宽 var trLen = spanLen/2/trtdNum; // 总行数 var lastTrNum = spanLen/2%trtdNum; //最后一行的个数 var lastColspan = trtdNum+1-lastTrNum; // 最后一行需要合并的单元格数 for (var j = 0; j < tdLen; j++) { for (var k = 0; k < trLen; k++) { if (parseInt(j / trtdNum) == k) { oContainer.find("td").eq(j).addClass("ic50-td" + k); } } } oContainer.find("td").css({"width": tdWidth + "px"}); // 设置列宽 oContainer.find("td:last-child").attr({"colspan": lastColspan}); //最后一行合并的单元格数量 oContainer.find("td:last-child").css({"width": lastColspan*tdWidth+"px"}); // 最后一列宽度 // tr 分组 for (var k = 0; k < trLen; k++) { oContainer.find(".ic50-td" + k).wrapAll(""); } } oContainer.find("td.ic50-td0 > p:first-child").css({"border-top":"0"}); // 第一行 p 的上border 是0 // 如果一行中 IC50 全是空，则这一行隐藏 var iTrLength = oContainer.find("tr>tr").length; var str = []; var tdLength = 0; console.log("tr="+iTrLength); for(var a = 0; a < iTrLength; a++){ tdLength = oContainer.find("tr>tr").eq(a).find("td").length; for(var b = 0; b < tdLength; b++ ){ var aa = oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).text().replace(/\,|(^\s*)|(\s*$)/g, ""); str[a] += aa; } console.log("str[a]="+str[a]); if(str[a] == "undefined" || str[a] == "" || str[a] == null){ for(var b = 0; b < tdLength; b++ ){ oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(1).css({"display":"none"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).css({"padding":"0"}); oContainer.find("tr>tr").eq(a).find("td").eq(b).find("p").eq(0).find("span").css({"padding":"8px 18px 6px"}); } } } } //最小值 Array.prototype.min = function() { var min = this[0]; var len = this.length; for (var i = 1; i < len; i++){ if (this[i] < min){ min = this[i]; } } return min; } //最大值 Array.prototype.max = function() { var max = this[0]; var len = this.length; for (var i = 1; i < len; i++){ if (this[i] > max) { max = this[i]; } } return max; } Number.prototype.toFloor = function (num) { return Math.floor(this * Math.pow(10, num)) / Math.pow(10, num); }; // end Product Isoform by WDF 20180203 //0){ return false; } else{ var count=$("#iqDetail_productCount").val().trim(); var amountUnit=$('#amountUnit option:selected').text(); $("#pro_num_p").html(count +" "+amountUnit); $(".form_submit_loading").show(); $(".btn_inquiry_submit").addClass("form_btn_submit_send") .removeClass("btn_inquiry_submit"); $("#btn_inquiry_submit").attr({"disabled":"disabled"}); $("#amountUnit").removeAttr("disabled"); $.ajax({ url:"mce_productDetail!inquiry.shtml", cache: false, data:$("#InquiryForm").serialize(), type:"POST", error: function(data) { $("#notice_titie").html("Uh-oh!"); $("#notice_content").html("It appears that we were unable to send an email to "+$("#cmInqriry_addrEmail1").val().trim()+". 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var lot_batch = $("#pdf_batch_no option:selected").text(); var pdf_coa = document.getElementById("productDetailBatch_pdf_coa"); var pdf_batch = document.getElementById("productDetailBatch_pdf_batch"); //alert(pdf_batch); //pdf_batch.innerHTML = ""; $(pdf_batch).html(""); var batch_txt = ""; var coa_txt = ""; for(var i=0;iCOA ("+arrPdf[i].objSize+" KB)"; }else if(arrPdf[i].objFile=="Elemental-Analysis-Report"){ coa_txt = coa_txt + "元素分析报告 ("+arrPdf[i].objSize+" KB)"; }else if(arrPdf[i].objFile=="HNMR"){ if (isShowPT) { coa_txt = coa_txt + "HNMR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "HNMR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-HNMR-link', arrPdf[i].objName, 'HNMR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="CNMR"){ if (isShowPT) { coa_txt = coa_txt + "CNMR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "CNMR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-CNMR-link', arrPdf[i].objName, 'CNMR', catalogNo, lot_batch); 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} else { coa_txt = coa_txt + "LCMS ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-LCMS-link', arrPdf[i].objName, 'LCMS', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="IR"){ if (isShowPT) { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "IR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-IR-link', arrPdf[i].objName, 'IR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="GC"){ if (isShowPT) { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "GC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-GC-link', arrPdf[i].objName, 'GC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="OR"){ if (isShowPT) { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "OR ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-OR-link', arrPdf[i].objName, 'OR', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SDS-PAGE"){ if (isShowPT) { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SDS-PAGE ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SDS-PAGE-link', arrPdf[i].objName, 'SDS-PAGE', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="Other Report"){ if (isShowPT) { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "Other Report ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-Other-Report-link', arrPdf[i].objName, 'Other Report', catalogNo, lot_batch); pdf_array.push(pdf_obj); } }else if(arrPdf[i].objFile=="SEC-HPLC"){ if (isShowPT) { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; } else { coa_txt = coa_txt + "SEC-HPLC ("+arrPdf[i].objSize+" KB)"; var pdf_obj = new $.PdfObj('J-SEC-HPLC-link', arrPdf[i].objName, 'SEC-HPLC', catalogNo, lot_batch); pdf_array.push(pdf_obj); } } }else{ if(arrPdf[i].objFile=="Purity"){ batch_txt += "纯度： " + arrPdf[i].objName ; } else if (arrPdf[i].objFile=="Assay") { batch_txt += "含量： " + arrPdf[i].objName; } else{ batch_txt += "ee.: " + arrPdf[i].objName ; } } } //pdf_batch.innerHTML = batch_txt; //pdf_coa.innerHTML = coa_txt; $("#productDetailBatch_pdf_batch").html(batch_txt); $("#productDetailBatch_pdf_coa").html(coa_txt); } } if (pdf_array.length>0) { $.each(pdf_array, function(index, pdfobjTemp){ //console.log(pdfobjTemp.pdfname); $("#" + pdfobjTemp.pdfid).click(function () { pagePdfObj = pdfobjTemp; pagePdfObj.proName = `Inactive ASO (in vivo) sodium`; $("#J-HNMR-form .title").html("Request for " + pagePdfObj.pdftype + " Report"); $("#J-HNMR-form #lotNo").val(pagePdfObj.lotNo); modalOpen("#J-HNMR-form"); getUserBaseMessage(); }); }); } } }); } function Gettext(obj){ var txt=obj.options[obj.options.selectedIndex].text; return txt; } cart_sart(); //]]> function findClinicalsByCatalogNo(){ var catalogNo = "HY-153734"; $.ajax({ url:'mce_productDetail!findClinicalsByCatalogNo.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'pro_catalogNo':catalogNo}, dataType: 'json', success:function(data){ var str_head = "" + "" + "NCT Number" + "Sponsor" + "Condition" + "Start Date" + "Phase" + "" + "" + ""; var str_foot = ""; var str_content = ""; $.each(data, function(i, item) { if (i==3) { //alert(i+","+item.phase); str_content += " "; } str_content += "" + item.nctNumber + ""; str_content += "" + item.sponsorCollaberators + ""; str_content += "
" + item.activeCondition + "
"; str_content += "" + item.startDate + ""; str_content += "" + item.phase + ""; }); $('#clinical_seo').html(str_head + str_content + str_foot); proClinicalStyle(); } }) } $("#datasheet_url").show(); $("#datasheet_footer_url").show(); $("#datasheet_span").show(); $("#sds_url").show(); $("#sds_footer_url").show(); $("#sds_span").show(); function checkUrl(c_url,type_id) { /*$.ajax({ url:'mce_productDetail!chenkUrlStatus.shtml?mathdom='+Math.random(), type: 'post', cache:false, data:{'curl':c_url}, dataType: 'json', success:function(data){ if (data.checkUrl == "success") { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } } })*/ $.ajax({ url: c_url, type: 'get', cache: false, dataType: 'jsonp', processData: false, complete: function(response) { if (response.status == 200) { $("#" + type_id + "_url").show(); $("#" + type_id + "_footer_url").show(); $("#" + type_id + "_span").show(); } }, error: function(data) {} }); } $(function(){ ChangerProductPdf($("#pdf_batch_no option:selected").val()); fnCPDRelated('#J-cpd-related-lib'); //fnCPDRelated('#J-cpd-related-mol'); //findRelatedProArray(); var pmsOutSessionId = $.cookie('pms-out-init'); console.log(pmsOutSessionId) //遮罩层屏蔽 if (pmsOutSessionId != "" && pmsOutSessionId !=null && pmsOutSessionId != undefined){ $("#loginProLogin").hide(); $("#loginProGeneral").hide(); $("#main").removeClass("gray-text");//遮罩层 $("#detail_price_pro").removeClass("is-disabled");//按钮控制 // // $("#loginProGeneral").hide(); // $("#loginProMask").removeClass("pro_mask"); } }); (function($, h, c) { var a = $([]), e = $.resize = $.extend($.resize, {}), i, k = "setTimeout", j = "resize", d = j + "-special-event", b = "delay", f = "throttleWindow"; e[b] = 350; e[f] = true; $.event.special[j] = { setup : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.add(l); $.data(this, d, { w : l.width(), h : l.height() }); if (a.length === 1) { g() } }, teardown : function() { if (!e[f] && this[k]) { return false } var l = $(this); a = a.not(l); l.removeData(d); if (!a.length) { clearTimeout(i) } }, add : function(l) { if (!e[f] && this[k]) { return false } var n; function m(s, o, p) { var q = $(this), r = $.data(this, d); r.w = o !== c ? o : q.width(); r.h = p !== c ? p : q.height(); n.apply(this, arguments) } if ($.isFunction(l)) { n = l; return m } else { n = l.handler; l.handler = m } } }; function g() { i = h[k](function() { a.each(function() { var n = $(this), m = n.width(), l = n.height(), o = $ .data(this, d); if (m !== o.w || l !== o.h) { n.trigger(j, [ o.w = m, o.h = l ]) } }); g() }, e[b]) } })(jQuery, this); $('#loginProLogin').on('mousedown', function() { $('#loginProLogin').css('cursor','grab') }); $('#loginProLogin').on('mouseup', function() { $('#loginProLogin').css('cursor','move') }); $('#loginProGeneral').on('mousedown', function() { $('#loginProGeneral').css('cursor','grab') }); $('#loginProGeneral').on('mouseup', function() { $('#loginProGeneral').css('cursor','move') });