2. Others NF-κB
  3. Isotope-Labeled Compounds NF-κB
  4. Indole-4-carboxaldehyde-13C

Indole-4-carboxaldehyde-13C 是 13C 标记的 Indole-4-carboxaldehyde (HY-W001288)。Indole-4-carboxaldehyde 是一种麦角生物碱前体。Indole-4-carboxaldehyde 可通过激活 NF-κB，减弱甲基乙二醛 (MGO) 诱导的炎症相关基因 (如 TNF-α 和 IFN-γ) 的表达，且对 HepG2 细胞无毒性。Indole-4-carboxaldehyde 可降低 MGO 诱导的晚期糖基化终产物 (AGE) 生成及其受体 (RAGE) 的表达。Indole-4-carboxaldehyde 可用于肝脂肪变性的研究。

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Indole-4-carboxaldehyde-<sup>13</sup>C

Indole-4-carboxaldehyde-13C Chemical Structure

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Other Forms of Indole-4-carboxaldehyde-13C:

Indole-4-carboxaldehyde-13C 相关抗体

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indole-4-carboxaldehyde-13C is the 13C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis[1][2].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indole-4-carboxaldehyde-13C 相关抗体:
分子量

146.15

Formula

C813CH7NO
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indole-4-carboxaldehyde-13C 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Indole-4-carboxaldehyde-13CIsotope-Labeled CompoundsNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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目录号：
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