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  2. Isotope-Labeled Compounds c-Myc Apoptosis
  3. Inosine-5'-diphosphate-15N4 dilithium

Inosine-5'-diphosphate-15N4 dilithium  (Synonyms: IDP-15N4 dilithium; Inosine-5'-diphosphoric acid-15N4 disodium)

目录号: HY-W013724S
产品使用指南 技术支持

Inosine-5'-diphosphate-15N4 dilithium (IDP-15N4 dilithium) 是 15N 标记的 Inosine-5'-diphosphate dilithium。Inosine-5'-diphosphate (IDP) 是一种 NM23-H2 的诱饵底物。Inosine-5'-diphosphate 在 NM23-H2 的 GDP 结合位点上具有优异的键合能力 (KD:5.0 μM)。Inosine-5'-diphosphate 通过破坏 NM23-H2-Pu27-GQ 相互作用,抑制 c-MYC 转录,诱导细胞凋亡 (apoptosis) 和 G2/M 细胞周期停滞,且不影响 NM23-H2 介导的激酶特性。Inosine-5'-diphosphate 具有抗缺氧、抗高血压和抗心律失常活性,还保护动物免受 γ 辐射的有害影响。Inosine-5'-diphosphate 可用于伯基特淋巴瘤等癌症和心血管疾病研究。

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Inosine-5'-diphosphate-<sup>15</sup>N<sub>4</sub> dilithium

Inosine-5'-diphosphate-15N4 dilithium Chemical Structure

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Other Forms of Inosine-5'-diphosphate-15N4 dilithium:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Inosine-5'-diphosphate-15N4 dilithium (IDP-15N4 dilithium) is 15N labeled Inosine-5'-diphosphate dilithium. Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research[1][2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

444.03

Formula

C10H12Li215N4O11P2

中文名称

5'-二磷酸肌苷二锂盐-15N4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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