2. Immunology/Inflammation
  3. CD3
  4. IOR-T3

IOR-T3 是靶向 CD3 的单克隆抗体，具备 T 细胞活化调控相关生物活性。IOR-T3 可变区竞争性结合淋巴细胞表面 CD3 靶点实现强效 T 细胞增殖激活。IOR-T3 及其衍生物可用于急性移植排斥反应的相关研究。

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IOR-T3

IOR-T3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

IOR-T3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IOR-T3 is a monoclonal antibody targeting CD3, with biological activities related to T cell activation regulation. IOR-T3 uses its variable region to competitively engage surface CD3 on lymphocytes and trigger robust T cell proliferation and activation. IOR-T3 and its derivatives can be used in studies related to acute transplant rejection[1][2].

反应种属

Human
体外研究
(In Vitro)

IOR-T3 (1 h) 可强效结合人外周血单个核细胞 (PBMC) 表面的 CD3，其抗原结合能力与嵌合变体 T3q 和 T3q (Ala=Ala) 相当[1]。
IOR-T3 (70-100 μg/mL; 7 days) 以 100 μg/mL 的浓度作用 7 天时，不会抑制人非小细胞肺癌 H125 细胞的生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IOR-T3 相关抗体:

Cell Proliferation Assay[2]

Cell Line: human non-small-cell lung carcinoma H125 cells
Concentration: 70, 90, 100 μg/mL
Incubation Time: 7 days
Result: Showed no inhibitory effect on H125 cell growth, with cell protein content remaining at 100% of control levels.
基因 ID

916  [NCBI]

Accession
靶点

CD3E
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IOR-T3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IOR-T3CD3Cluster of differentiation 3human PBMCshuman non-small-cell lung carcinoma cellsacute transplant rejectionhuman non-small-cell lung carcinoma H125 cellshuman peripheral blood mononuclear cellsIgG 2A monoclonal antibodyInhibitorinhibitorinhibit

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