2. Immunology/Inflammation Apoptosis
  3. IRAK TNF Receptor IFNAR
  4. IRAK4-IN-33

IRAK4-IN-33 (Compound 22) 是一种选择性、强效且具有口服活性的白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂，其 IC50 值为 0.36 nM。IRAK4-IN-33 能够阻断由 IRAK4 介导的促炎信号通路，并抑制 TNFα 和 IFNα 的释放。IRAK4-IN-33 对 hERG 通道的抑制作用较弱 (IC50 值大于 30 μM)。IRAK4-IN-33 可用于炎症和免疫学研究，如类风湿性关节炎。

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IRAK4-IN-33

IRAK4-IN-33 Chemical Structure

CAS No. : 2411497-72-6

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IRAK4-IN-33 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

查看所有亚型
IRAK1 IRAK4

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRAK4-IN-33 (Compound 22) is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 0.36 nM. IRAK4-IN-33 can block the pro-inflammatory signaling pathway mediated by IRAK4 and inhibit the release of TNFα and IFNα. IRAK4-IN-33 shows weak inhibition for hERG channel (IC50 > 30 μM). IRAK4-IN-33 can be used for the research of inflammation and immunology, such as rheumatoid arthritis[1].

分子量

538.63

Formula

C27H26N10OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IRAK4-IN-33 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-332411497-72-6IRAKTNF ReceptorIFNARInterleukin-1 receptor associated kinaseIL-1R associated kinaseTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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产品名称：
IRAK4-IN-33
目录号：
HY-180579
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