2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism
  4. IRW

IRW 是一种从蛋清中提取的具有口服活性的三肽，具有血管紧张素转换酶 (ACE) 抑制特性。IRW 可通过调节肝脏脂质代谢和增加线粒体含量，预防高脂饮食 (HFD) 诱导的非酒精性脂肪肝 (NAFLD)。IRW 能降低肝脏甘油三酯含量和脂滴大小。IRW 可增加肝脏线粒体复合物和柠檬酸合酶活性、5'-AMP 激活蛋白激酶的磷酸化以及微粒体甘油三酯转移蛋白的丰度。IRW 能增加磷酸化的乙酰辅酶 A 羧化酶 (acetyl CoA carboxylase) 和线粒体复合物，可用于炎症相关研究。

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IRW

IRW Chemical Structure

CAS No. : 159718-10-2

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IRW 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation[1].

体内研究
(In Vivo)

IRW (45 mg/kg，口服，每日一次，持续 8 周) 可预防高脂饮食 (HFD) 诱导的 C57BL/6 小鼠的非酒精性脂肪肝 (NAFLD)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with high-fat diet (HFD)[1]
Dosage: 45 mg/kg, diet
Administration: Orally administration, daily for 8 weeks
Result: Decreased hepatic triglyceride content and lipid droplet size.
Increased the abundance of hepatic mitochondrial complexes (Ⅰ-Ⅴ) and citrate synthase activity.
Improved glucose tolerance and reduced fasting blood glucose.
Decreased body weight gain and enhanced hepatic phosphorylated acetyl-CoA carboxylase (p-ACC) levels.
Increased adiponectin content in retroperitoneal white adipose tissue (rWAT).
分子量

473.57

Formula

C23H35N7O4
CAS 号
Sequence

Ile-Arg-Trp
Sequence Shortening

IRW
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IRW 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRW159718-10-2Angiotensin-converting Enzyme (ACE)Acetyl-CoA CarboxylaseMitochondrial MetabolismACC, Acetyl Coenzyme A Carboxylaseangiotensin converting enzymeACEHFDNAFLDmitochondrial complexestriglyceridecitrate synthase5’-AMP-activated protein kinaseacetyl CoA carboxylaseinflammationInhibitorinhibitorinhibit

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