2. Metabolic Enzyme/Protease Immunology/Inflammation MAPK/ERK Pathway Stem Cell/Wnt
  3. Thrombin COX ERK JNK Factor Xa
  4. Isorhamnetin 3-O-galactoside

Isorhamnetin 3-O-galactoside  (Synonyms: 异鼠李素-3-O-半乳糖苷; Cacticin)

目录号: HY-N2082 纯度: 99.64%
COA 产品使用指南 技术支持

Isorhamnetin 3-O-galactoside (Cacticin) 是一种黄酮苷，可从 Oenanthe javanica 中分离，具有抗血栓和促纤溶活性。Isorhamnetin 3-O-galactoside 抑制凝血酶 (thrombin) 和因子 Xa (FXa) 的活性，降低凝血酶催化的纤维蛋白聚合作用的最大速率。Isorhamnetin 3-O-galactoside 抑制 TNF-α 诱导的 PAI-1 分泌，降低 PAI-1/组织型纤溶酶原激活物 (t-PA) 比率，并抑制 FXa 产生和 FVa/FXa 介导的凝血酶生成。Isorhamnetin 3-O-galactoside 对 Carbon tetrachloride (CCl4) (HY-Y0298) 诱导的小鼠肝损伤具有保护作用。Isorhamnetin 3-O-galactoside 可用于肝损伤相关疾病和血栓性血管疾病的研究。

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Isorhamnetin 3-O-galactoside

Isorhamnetin 3-O-galactoside Chemical Structure

CAS No. : 6743-92-6

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1 mg ￥1200
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10 mg ￥5200
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Isorhamnetin 3-O-galactoside 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BMDC IC50
> 50 μM
Compound: 11
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
[PMID: 25769817]
BMDC IC50
> 50 μM
Compound: 11
Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
[PMID: 25769817]
BMDC IC50
> 50 μM
Compound: 11
Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
[PMID: 25769817]
C2C12 EC50
18.5 μM
Compound: 6
Increase in glucose uptake in mouse C2C12 cells incubated for 18 hrs using [3H]-2-deoxy-D-glucose by liquid scintillation counting
Increase in glucose uptake in mouse C2C12 cells incubated for 18 hrs using [3H]-2-deoxy-D-glucose by liquid scintillation counting
[PMID: 22738356]
Monocyte IC50
3.8 μM
Compound: isorhamnetin 3-glucoside
Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs
Inhibition of procoagulant activity in monocyte from human blood assessed as counteraction of IL1-induced tissue factor expression after 18 hrs
[PMID: 8882428]
体外研究
(In Vitro)

Isorhamnetin 3-O-galactoside (0.5-50 μM) 抑制 HUVECs 中 TNF-α/FVIIa 介导的凝血酶和 FXa 产生[2]。
Isorhamnetin 3-O-galactoside (0.5-50 μM, 18 h) 以剂量依赖性方式抑制 HUVECs 中 TNF-α 诱导的 PAI-1 分泌[2]。
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) 有效抑制 LPS (100 ng/mL, 16 h) 诱导的 HUVECs 中 HMGB1 的释放[3]。
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) 可减轻 LPS 或 HMGB1 诱导的屏障破坏[3]。
Isorhamnetin 3-O-galactoside (5 μM, 6 h) 抑制 HMGB1 诱导的 HUVECs 中细胞间隙形成，并促进致密 F-actin 环的形成，从而维持内皮细胞的形态完整性[3]。
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) 抑制 HMGB1 诱导的 HUVECs 中血管细胞黏附分子-1 (VCAM-1) 的表达[3]。
Isorhamnetin 3-O-galactoside (1-5 μM, 6 h) 显著抑制 HUVEC 核提取物中 HMGB1 诱导的磷酸化 NF-κB p65 和 TNF-α 的激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isorhamnetin 3-O-galactoside 相关抗体:
体内研究
(In Vivo)

Isorhamnetin 3-O-galactoside (50-200 mg/kg, 腹腔注射, 两次：CCl4 注射前 30 分钟和注射后 2 小时) 减轻雄性 ICR 小鼠中 CCl4 诱导的肝损伤[1]。
Isorhamnetin 3-O-galactoside (2.4 mg/kg, 静脉给药, 一次) 显著延长尾部出血时间[2]。
Isorhamnetin 3-O-galactoside (4.8 mg/只小鼠，静脉注射，单次给药) 在盲肠结扎穿孔 (CLP) 诱导的脓毒症雄性 C57BL/6 小鼠中显著抑制 HMGB1 的释放[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (25-30 g) were intraperitoneally injected with CCl4[1]
Dosage: 50, 100, 200 mg/kg
Administration: i.p., twice: 30 min before and 2 h after CCl4 injection
Result: Attenuated ALT and AST activities.
Reduced MDA and TNF-α levels.
Inhibited CCl4-induced upregulation of hepatic iNOS and COX-2 protein and mRNA expression, and enhanced CCl4-induced increase in hepatic HO-1 protein and mRNA expression.
Reduced the expression of JNK, ERK, and NF-κB.
分子量

478.40

Formula

C22H22O12
CAS 号
性状

固体

颜色

White to yellow

中文名称

异鼠李素-3-O-半乳糖苷
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (209.03 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0903 mL 10.4515 mL 20.9030 mL
5 mM 0.4181 mL 2.0903 mL 4.1806 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.64%

COA (295 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

Isorhamnetin 3-O-galactoside 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0903 mL 10.4515 mL 20.9030 mL 52.2575 mL
5 mM 0.4181 mL 2.0903 mL 4.1806 mL 10.4515 mL
10 mM 0.2090 mL 1.0452 mL 2.0903 mL 5.2258 mL
15 mM 0.1394 mL 0.6968 mL 1.3935 mL 3.4838 mL
20 mM 0.1045 mL 0.5226 mL 1.0452 mL 2.6129 mL
25 mM 0.0836 mL 0.4181 mL 0.8361 mL 2.0903 mL
30 mM 0.0697 mL 0.3484 mL 0.6968 mL 1.7419 mL
40 mM 0.0523 mL 0.2613 mL 0.5226 mL 1.3064 mL
50 mM 0.0418 mL 0.2090 mL 0.4181 mL 1.0452 mL
60 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8710 mL
80 mM 0.0261 mL 0.1306 mL 0.2613 mL 0.6532 mL
100 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5226 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isorhamnetin 3-O-galactoside6743-92-6Cacticin异鼠李素-3-O-半乳糖苷ThrombinCOXERKJNKFactor XaCyclooxygenaseExtracellular signal regulated kinasesc-Jun N-terminal kinaseFxaliver injury-related diseasesthrombotic vascular diseasesOenanthe javanicathrombinInhibitorinhibitorinhibit

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