2. NF-κB Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation
  3. Keap1-Nrf2 Heme Oxygenase (HO) JNK ERK p38 MAPK NF-κB Interleukin Related
  4. Isostrictiniin

Isostrictiniin (ITN) 是一种多酚类化合物，可从 Nymphaea candida 中分离得到。Isostrictiniin 可上调 Nrf2 和 HO-1 的表达，下调 Keap1 的表达。Isostrictiniin 可降低 JNK、ERK1/2、p38、IκBα 和 NF-κB p65 的磷酸化蛋白表达。Isostrictiniin 降低促炎介质 (IL-1β、IL-6、TNF-α、PGE2) 的水平。Isostrictiniin 可减轻 LPS 诱导的急性肺损伤，对急性酒精性肝损伤具有保护作用。Isostrictiniin 还具有抗炎、抗氧化和抗纤维化活性。

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Isostrictiniin

Isostrictiniin Chemical Structure

CAS No. : 1801746-41-7

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Isostrictiniin 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

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HO-1 HO-2

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JNK1 JNK2 JNK3 JNK

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isostrictiniin (ITN) is a polyphenolic compound isolated from Nymphaea candida. It upregulates the expression of Nrf2 and HO-1, while downregulating the expression of Keap1. Isostrictiniin reduces the phosphorylation levels of JNK, ERK1/2, p38, IκBα, and NF-κB p65. Isostrictiniin decreases the levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, PGE2). Isostrictiniin alleviates LPS-induced acute lung injury and exerts protective effects against acute alcoholic liver injury. Additionally, isostrictiniin exhibits anti-inflammatory, antioxidant, and anti-fibrotic activities.

IC50 & Target[2]

ERK1

 

ERK2

 

p38

 

IL-6

 

IL-1β

 

体外研究
(In Vitro)

Isostrictiniin (50-200 μM；12 h) 可抑制 A549 细胞增殖，使细胞存活率降至 80% 以下[2]。
Isostrictiniin (5-25 μM；处理 12 h) 可降低 LPS 诱导的 A549 细胞中促炎介质 (IL-1β、IL-6、TNF-α、PGE2) 的水平[2]。
Isostrictiniin (10-25 μM；作用 12 h) 可上调 LPS 诱导的 A549 细胞中 Nrf2 和 HO-1 的表达，降低该细胞中 Keap1 的表达，从而调控 Keap1-Nrf2/HO-1 通路[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isostrictiniin 相关抗体:

Western Blot Analysis[2]

Cell Line: LPS-induced A549
Concentration: 10-25 μM (with LPS)
Incubation Time: 12 h
Result: Upregulated Nrf2 and HO-1 protein expressions (p < 0.05) at both concentrations; markedly reduced Keap1 protein expression (p < 0.05) at 25 μM compared to the model group.

Western Blot Analysis[2]

Cell Line: LPS-induced A549
Concentration: 5-25 μM (with LPS)
Incubation Time: 12 h
Result: Reduced phosphorylated protein expressions of JNK, ERK1/2, p38, IκBα, and NF-κB p65 (p < 0.05) compared to the model group.
体内研究
(In Vivo)

Isostrictiniin (25-100 mg/kg；灌胃给药；每日 1 次；连续 7 天) 可通过呈剂量依赖性的方式减轻炎症反应、氧化应激及组织病理学损伤，从而缓解小鼠体内由 LPS 诱导的急性肺损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming (weight 18–20 g)[2]
Dosage: 25, 50, 100 mg/kg
Administration: intragastric; once daily; 7 days
Result: Significantly reduced lung indexes (p < 0.05), lung wet-to-dry (W/D) ratio, bronchoalveolar lavage fluid (BALF) protein leakage, and BALF white blood cell (WBC) counts (p < 0.01) at 25, 50, 100 mg/kg. Reduced lung tissue myeloperoxidase (MPO) activity (p < 0.05), lung tissue tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels (p < 0.01) at 50, 100 mg/kg. Suppressed blood neutrophil counts, elevated lymphocyte counts (p < 0.01), reduced lung tissue malondialdehyde (MDA) levels, and increased superoxide dismutase (SOD) and glutathione (GSH) levels (p < 0.05) at 100 mg/kg. Improved lung histopathological damage and reduced pathological scores (p < 0.05) at 25, 50, 100 mg/kg.
分子量

634.45

Formula

C27H22O18
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Isostrictiniin 相关分类

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Keywords:

Isostrictiniin1801746-41-7ITNKeap1-Nrf2Heme Oxygenase (HO)JNKERKp38 MAPKNF-κBInterleukin RelatedHeme Oxygenasec-Jun N-terminal kinaseExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBILNF-κB p65A549 cellsmouse modelsHO-1Nrf2p38IκBαERK1/2Keap1Inhibitorinhibitorinhibit

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