2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. JHU-083

JHU-083 是 6-diazo-5-oxo-L-norleucine (DON; HY-108357) 的前体，是一种口服有效的，选择性的谷氨酰胺酶 (glutaminase) 拮抗剂，可阻断脑 CD11b+ 细胞和实验性脑疟疾 (ECM) 中的谷氨酰胺酶，导致动物中谷氨酸水平的净降低。

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JHU-083

JHU-083 Chemical Structure

CAS No. : 1998725-11-3

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1 mg ￥2650
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5 mg ￥4400
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JHU-083 相关抗体

Top Publications Citing Use of Products

    JHU-083 purchased from MCE. Usage Cited in: Front Immunol. 2022 May 19:13:880262.  [Abstract]

    JHU-083 (0.3mg/kg; i.v; single) significantly decreases TUNEL-positive cells in mice, which indicates that JHU-083 ameliorates the progression of ConA-induced autoimmune hepatitis by blocking glutamine metabolism in mice.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].

    体内研究
    (In Vivo)

    JHU-083 (1.82 mg/kg；口服；每隔一天一次，持续 12 天) 改善由 CSDS 诱导的社交回避行为和快感缺乏样行为[1]。
    JHU-083 (1.82 mg/kg；口服) 减弱 CSDS 诱导的前额皮质和海马 CD11b+ 细胞中谷氨酰胺酶活性的增加，但不影响小脑。JHU-083 处理可抑制 CSDS 诱导的 IL-1β 和 TNF-α 表达上调[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male 7-to 8-week-old C57BL/6J (C57) mice (25-30 g) with chronic social defeat stress (CSDS)[1]
    Dosage: 1.82 mg/kg
    Administration: PO; every other day for 12 days
    Result: Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS.
    分子量

    312.36

    Formula

    C14H24N4O4
    CAS 号
    性状

    固体

    颜色

    Light yellow to yellow

    运输条件

    Shipping with dry ice.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料

    纯度: ≥98.0%

    COA (286 KB) HNMR (228 KB)

    产品使用指南 (1538 KB)
    参考文献

    JHU-083 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

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    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JHU-0831998725-11-3JHU083JHU 083Glutaminase6-diazo-5-oxo-L-norleucineDONorallybrainCD11b+experimentalcerebralmalariaECMInhibitorinhibitorinhibit

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    产品名称：
    JHU-083
    目录号：
    HY-122218
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