2. PROTAC Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. PROTACs HDAC Apoptosis
  4. JPS004

JPS004 是一种 HDAC1-3 PROTAC 降解剂。JPS004 能够诱导 HDAC1-3 降解并诱导组蛋白乙酰化。JPS004 可以诱导癌细胞凋亡 (apoptosis)。JPS004 可用于癌症研究。(结构：粉色：HDAC1-3 配体 (HY-50934)；蓝色：VHL 连接酶配体 (HY-125845)；HDAC1-3 配体-Linker： (HY-176905))

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JPS004

JPS004 Chemical Structure

CAS No. : 2559747-12-3

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JPS004 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer[1]. (Structure Note: Pink: HDAC1-3 ligand (HY-50934); Blue: VHL ligand (HY-125845); HDAC1-3 ligand-Linker: (HY-176905))

IC50 & Target[1]

VHL

 

HDAC1

 

HDAC2

 

HDAC3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 EC50
4.3 μM
Compound: 1; JPS004
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
[PMID: 35293758]
体外研究
(In Vitro)

JPS004 (10 μM, 24 h) 在人结直肠癌细胞 HCT116 中，可有效降解 HDAC 1、2、3，并升高组蛋白 H3 赖氨酸 56 位乙酰化 (H3K56ac) 和组蛋白 H2B 赖氨酸 5 位乙酰化 (H2BK5ac) 水平[1]。
JPS004 (10 μM, 24 h) 诱导 HCT116 细胞凋亡，但不影响凋亡抑制蛋白 cIAP2 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JPS004 相关抗体:
分子量

852.10

Formula

C47H61N7O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JPS004 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JPS0042559747-12-3JPS 004JPS-004PROTACsHDACApoptosisHistone deacetylasesPROTAChistoneapoptosisCancerHCT116Inhibitorinhibitorinhibit

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目录号：
HY-176904
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