2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. JSD26

JSD26 是一种选择性口服活性 SCoR2 (AKR1A1) 抑制剂，IC50 为 93 nM。JSD26 对 SCoR2 的选择性是 AKR1B1 的 10 倍。JSD26 可用于急性肾损伤 (AKI) 的研究。

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JSD26

JSD26 Chemical Structure

CAS No. : 2353515-08-7

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JSD26 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI)[1].

IC50 & Target

SCoR2

93 nM (IC50)

体内研究
(In Vivo)

JSD26 (20-120 mg/kg，腹腔注射，单次) 可有效抑制小鼠体内的 SCoR2，且不影响 AKR1B1[1]。
JSD26 (120 mg/kg，腹腔注射，单次) 可通过选择性抑制 SCoR2 并增加 PKM2的 S-亚硝基化，从而缓解急性肾损伤 (AKI) 小鼠的症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy C57BL/6J mice[1].
Dosage: 20 mg/kg, 40 mg/kg, 80 mg/kg, 120 mg/kg
Administration: I.p., once
Result: At the highest dose (120 mg/kg), renal SCoR2 activity was inhibited by 80%.
Did not inhibit renal AKR1B1 activity and inhibited SCoR2 in other organs (liver, lung, heart, spleen), but showed no inhibition in brain tissue, indicating that it cannot cross the blood-brain barrier.
Animal Model: Male C57BL/6J (9–11 weeks, 25–28 g) were induced with AKI via ischemia-reperfusion (I/R) surgery[1].
Dosage: 120 mg/kg
Administration: I.p., once
Result: Renal SCoR2 activity was inhibited by 80%, but SCoR2 protein expression levels remained unchanged.
Serious creatinine and BUN levels were significantly reduced, indicating improved renal function.
Histological analysis (H&E staining) showed reduced tubular damage in the JSD26 treatment group (e.g., reduced tubular dissolution and debris).
PKM2 S-nitrosylation (SNO-PKM2) levels were increased, and PKM2 activity was decreased.
分子量

290.32

Formula

C18H14N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JSD26 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JSD262353515-08-7JSD 26JSD-26Aldose ReductaseAcute Kidney InjuryAKISCoR2 InhibitorAKR1A1PKM2Inhibitorinhibitorinhibit

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