2. Neuronal Signaling TGF-beta/Smad Epigenetics Apoptosis
  3. PKC Amyloid-β CaMK Apoptosis
  4. Junicedric acid

Junicedric acid 是一种二萜类化合物，能从 Araucaria araucana 树脂中分离得到。Junicedric acid 通过增加海马神经元胞内钙水平，激活 PKC 和钙调蛋白依赖性蛋白激酶 CaMKII，发挥神经保护活性，可阻止 β-淀粉样蛋白 (Aβ) 寡聚体诱导的突触蛋白丢失、凋亡 (apoptosis) 及长时程增强 (LTP) 抑制。Junicedric acid 可用于阿尔茨海默病等神经退行性疾病的病理机制研究。

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Junicedric acid

Junicedric acid Chemical Structure

CAS No. : 41787-69-3

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Junicedric acid 相关抗体

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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  • 生物活性

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生物活性

Junicedric acid is a diterpenoid compound that can be isolated from the resin of the Araucaria araucana tree. Junicedric acid exerts neuroprotective activity by increasing intracellular calcium levels in hippocampal neurons, activating PKC and calcium/calmodulin-dependent protein kinase (CaMKII), and preventing Amyloid-β oligomer-induced synaptic protein loss, apoptosis, and long-term potentiation (LTP) inhibition. Junicedric acid can be used in the study of the pathological mechanisms of neurodegenerative diseases such as Alzheimer's disease[1].

IC50 & Target

CaMK II

 

分子量

336.47

Formula

C20H32O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Junicedric acid 相关分类

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Keywords:

Junicedric acid41787-69-3PKCAmyloid-βCaMKApoptosisProtein kinase Cβ-amyloid peptideAβAbetaCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesInhibitorinhibitorinhibit

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