2. TGF-beta/Smad
  3. TGF-β Receptor
  4. K02288

K02288 (GMP) 是 GMP 级别的 K02288 (HY-12278)。GMP 级别的小分子可用做细胞疗法中的辅助试剂。K02288 是一种有效的骨形态发生蛋白 (BMP) I 型受体抑制剂，抑制 ALK1，ALK2，ALK6 的 IC50 为 1.8，1.1，6.4 nM。对 ALK3 和 ALK6 的抑制稍弱，IC50在 5-34 nM 之间。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

K02288

K02288 Chemical Structure

CAS No. : 1431985-92-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

K02288 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K02288 (GMP) is K02288 (HY-12278) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.

体外研究
(In Vitro)

K02288 (GMP)降低由 BMP4 刺激诱导的 Smad1/5/8 的强烈磷酸化，表观 IC50 值为 100 nM。K02288 (GMP) 在 0.5 μM 时几乎完全抑制 Smad2 磷酸化[1]。
K02288 (GMP) 以 ATP 模拟方式与 ALK1 结合，两个氢键与激酶铰链相连。K02288 (GMP) 还抑制 BMP9-ALK1 信号传导，并在 HUVECs 中诱导过度萌发表型[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K02288 相关抗体:
体内研究
(In Vivo)

K02288 (GMP) (1 μM) 在鸡胚 CAM 模型中诱导功能失调的血管生成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

352.38

Formula

C20H20N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K02288 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K02288 (GMP)1431985-92-0TGF-β ReceptorTransforming growth factor beta receptorsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
K02288
目录号：
HY-12278G
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z