2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-042

KBP-042 是一种口服有效的胰淀素受体激活剂，同时也是降钙素受体激活剂。KBP-042 可诱导持续性体重减轻、减少脂肪组织量、降低肝脏脂质沉积、提高血浆脂联素水平、降低血浆瘦素水平，并降低血浆葡萄糖依赖性促胰岛素多肽水平。KBP-042 可用于肥胖和胰岛素抵抗的相关研究。

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Custom Peptide Synthesis

KBP-042

KBP-042 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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规格 是否有货
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Customer Review

KBP-042 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KBP-042 is an orally active amylin receptor activator, a calcitonin receptor activator. KBP-042 induces sustained weight loss, reduces adipose tissue mass, lowers hepatic lipid deposition, increases plasma adiponectin, decreases plasma leptin, and reduces plasma glucose-dependent insulinotropic peptide levels. KBP-042 can be used for the research of obesity and insulin resistance[1].

体内研究
(In Vivo)

KBP-042 (0.625-10 μg/kg；皮下注射；每日 1 次；连续 56 天) 可在肥胖、胰岛素抵抗大鼠中诱导持续体重减轻 (最高达 20%)，减少脂肪组织和肝脏脂质堆积 (在 2.5 μg/kg 和 10 μg/kg 剂量下对肝脏 TAG 的作用具有统计学显著性)，改善葡萄糖耐量，并提升胰岛素敏感性 (葡萄糖输注速率提升 82%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 6 weeks old at study start, fed 60% fat kcal high-fat diet for 10 weeks to induce obesity and prediabetic status)[1]
Dosage: 0.625-10 μg/kg (8-week treatment); 5 μg/kg (hyperinsulinemic-euglycemic clamp)
Administration: s.c.; daily; 56 days (8-week treatment); 21 days (hyperinsulinemic-euglycemic clamp)
Result: Induced a dose-dependent, sustained weight loss up to 20% compared to high-fat diet vehicle; caused significant weight reduction at 2.5, 5, and 10 μg/kg vs. vehicle. Reduced epididymal and perirenal adipose tissue weights significantly at 10 μg/kg; reduced perirenal adipose tissue also at 2.5 and 5 μg/kg. Reduced hepatic triacylglycerol accumulation significantly at 2.5 μg/kg and 10 μg/kg. Increased plasma adiponectin significantly at 1.25, 2.5, 5, and 10 μg/kg; reduced plasma leptin significantly at 10 μg/kg. Showed impaired glucose tolerance (increased total area under the curve) at 10 μg/kg in acute OGTT, but reduced glucose total area under the curve at 2.5, 5, and 10 μg/kg vs. vehicle after 3 weeks of chronic treatment; improved glucose tolerance at 5 and 10 μg/kg after 7 weeks. Reduced insulin total area under the curve at 1.25-10 μg/kg after 3 weeks of IVGTT and at 2.5 and 5 μg/kg after 7 weeks while maintaining glucose tolerance. Increased glucose infusion rate by 82% vs. high-fat diet vehicle (and 27% vs. normal diet controls) during hyperinsulinemic-euglycemic clamp at 5 μg/kg.
分子量

3483.93

Formula

C149H244N44O48S2
Sequence

Ac-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2 (Disulfide bridge: Cys1-Cys7)
Sequence Shortening

Ac-CSNLSTCVLGKLSQELHKLQTYPRTDVGANAP-NH2 (Disulfide bridge: Cys1-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KBP-042 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-042KBP042KBP 042Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorcalcitonin receptoradipose tissueinsulin resistanceglucose-dependent insulinotropic peptideplasma leptinplasma adiponectinhepatic lipid depositiongastric emptyingamylin receptorobesityInhibitorinhibitorinhibit

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产品名称：
KBP-042
目录号：
HY-P11588
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