2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-066A

KBP-066A 是一种长效胰淀素 (amylin) 与降钙素受体 (calcitonin receptor) 双重激动剂。KBP-066A 可强效激活 CTR 和 AMY-R，且无脱靶活性。KBP-066A 可降低糖尿病大鼠模型的空腹血糖水平、空腹胰岛素水平及体重。KBP-066A 可用于 2 型糖尿病、肥胖症的研究。

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Custom Peptide Synthesis

KBP-066A

KBP-066A Chemical Structure

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Customer Review

KBP-066A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KBP-066A is a long-acting dual amylin and calcitonin receptor agonist. KBP-066A can activate the CTR and AMY-R potently, with no off-target activity. KBP-066A reduces fasting blood glucose levels, fasting insulin levels, and body weight in diabetic rat models. KBP-066A can be used for the research of type 2 diabetes mellitus, obesity[1].

体外研究
(In Vitro)

KBP-066A (25 μM、5 倍梯度稀释) 以浓度依赖的方式与 AMY3R 结合[1]。
KBP-066A 可激活 CTR (U20S CALCR) 和 AMY3R (CHO K1 CALCR RAMP3) 细胞，对所测试的降钙素样受体无脱靶活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KBP-066A 相关抗体:
体内研究
(In Vivo)

KBP-066A (1-4 nmol/kg；皮下注射；每 3 天 1 次；持续 4 周) 可在肥胖大鼠中诱导显著的、剂量依赖性体重下降，并改善血糖控制[1]。
KBP-066A (0.75-3 nmol/kg；皮下注射；每 3 天 1 次；持续 8 周) 可改善糖尿病 ZDF 大鼠的血糖状态[1]。
KBP-066A (0.5-36 nmol/kg；皮下注射；单剂量) 可在肥胖大鼠中产生剂量依赖性的急性摄食量降低和体重减轻作用，且剂量越高作用持续时间越长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 5-6 weeks old at arrival, baseline weight 528.2 ± 27.9 g at study start, obese via 60 kcal% fat high-fat diet for 20 weeks)[1]
Dosage: 1, 2, 4 nmol/kg
Administration: s.c.; every third day; 4 weeks
Result: Reduced body weight tAUC to 2584 ± 7, 2452 ± 6, 2458 ± 8 g days⁻¹ vs. vehicle 2773 ± 4 g days⁻¹.
Reduced accumulated food intake tAUC to 617 ± 10, 518 ± 6, 532 ± 10 g days⁻¹ vs. vehicle 811 ± 11 g days⁻¹.
Reduced perirenal adipose tissue in 2 and 4 nmol/kg groups.
Improved oral glucose tolerance (non-significant iAUC vs. vehicle).
Reduced plasma insulin iAUC and HOMA-IR significantly.
Animal Model: Zucker Diabetic Fatty (ZDF) (male, 5-6 weeks old at arrival, baseline weight 334.1 ± 15.5 g, baseline fasting blood glucose 14 ± 5.1 mM, baseline plasma insulin 8.0 ± 3.9 ng/mL)[1]
Dosage: 0.75, 1.5, 3 nmol/kg
Administration: S.c.; every third day; 8 weeks
Result: Reduced fasting blood glucose tAUC to 6180 ± 67, 6405 ± 89, 6409 ± 122 vs. vehicle 6475 ± 103.
Reduced accumulated food intake tAUC to 3815 ± 135, 3134 ± 111, 2898 ± 61 g*days⁻¹ vs. vehicle 4453 ± 123 g*days⁻¹.
Reduced HbA1c and significantly improved oral glucose tolerance iAUC at 3 nmol/kg dose.
Showed no significant body weight reduction.
分子量

4173.76

Formula

C182H303N47O60S2
Sequence

Ac-Cys-Ser-Asn-Leu-Ser-Thr-Cys-{Aib}-Leu-Gly-{Lys(2OEG-γGlu-C18 diacid)}-Leu-Ser-Gln-Asp-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Lys-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2
Sequence Shortening

Ac-CSNLSTC-{Aib}-LG-{K(2OEG-γGlu-C18 diacid)}-LSQDLHRLQTYPKTDVGANAP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KBP-066A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-066AAmylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorcalcitonin receptorU20S CALCR cellsCHO K1 CALCR RAMP3 cellstype 2 diabetes mellituscalcitonin-like receptorsAMY3Robese high-fat diet rat modelsamylin receptorZucker Diabetic Fatty rat modelsobesityInhibitorinhibitorinhibit

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目录号：
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