2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-089

KBP-089 是双重淀粉样蛋白 (Amylin) 和降钙素受体 (Calcitonin Receptor) 激动剂。KBP-089 能在肥胖大鼠中实现体重降低、脂肪组织减少并改善葡萄糖耐量，也可清除肝脏和肌肉的脂质积累、改善血糖稳态与胰岛素敏感性。KBP-089 可用于肥胖、2 型糖尿病等疾病的研究。

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Custom Peptide Synthesis

KBP-089

KBP-089 Chemical Structure

CAS No. : 1776112-67-4

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KBP-089 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KBP-089 is a dual Amylin and Calcitonin Receptor agonist. KBP-089 reduces body weight, decreases adipose tissue mass and improves glucose tolerance in obese rats. KBP-089 also eliminates lipid accumulation in the liver and muscle, and ameliorates glycemic homeostasis and insulin sensitivity. KBP-089 is applicable to the research of diseases such as obesity and type 2 diabetes[1][2].

体外研究
(In Vitro)

KBP-089 (3 小时) 可在异源细胞系中强效激活人 CTR 和 AMY3-R，其 pEC50 值介于 8.7 至 9.9 之间，且可诱导受体持续激活长达 72 小时[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KBP-089 相关抗体:
体内研究
(In Vivo)

KBP-089 (5 μg/kg；皮下注射；每日 1 次/隔日 1 次；15 天) 在高脂饮食喂养的大鼠中均可产生程度相当的体重降低效果[1]。
KBP-089 (0.625-40 μg/kg；皮下注射；6 周) 在高脂饮食喂养的大鼠中经 4 倍剂量递增给药后，可降低体重并改善其葡萄糖耐量[1]。
KBP-089 (0.625-40 μg/kg；皮下注射；单剂量) 可在 48 小时内剂量依赖性地抑制过夜禁食的高脂饮食喂养大鼠的热量摄入[1]。
KBP-089 (5-20 μg/kg；皮下注射；总计 8 周) 可降低糖尿病肥胖大鼠的血糖水平、改善其葡萄糖耐量并增强胰岛素作用[2]。
KBP-089 (2.5 µg/kg；皮下注射； 7 天) 可减少正常饮食喂养大鼠的总热量摄入，并使其食物偏好从巧克力转向普通饲料[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley (male, 18 weeks of age, high-fat diet-induced obesity model)[1]
Dosage: 0.625, 2.5, 10, 40 μg/kg
Administration: s.c.; 4-fold dose escalation followed by 6 weeks of maintenance at final dose
Result: Induced transient food intake reduction at each dose escalation step (magnitude decreasing over time).
Caused ~15% vehicle-corrected weight loss, corresponding adipose tissue reduction, and improved oral glucose tolerance at 2.5, 10, or 40 μg/kg.
Animal Model: Zucker Diabetic Fatty (ZDF-Leprfa/Crl) rats (male, 6 weeks old)[2]
Dosage: 5 µg/kg (first 4 weeks) and 20 µg/kg (additional 4 weeks)
Administration: s.c.; daily; 8 weeks total
Result: Reduced fasting blood glucose over 7 weeks.
Reduced HbA1c at study end; Lowered oral glucose tolerance test tAUC.
Increased insulin sensitivity.
分子量

3529.98

Formula

C148H242N46O48S3
CAS 号
Sequence

Ac-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Arg-Leu-Ser-Gln-Asp-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Lys-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2 (Disulfide bridge: Cys1-Cys7)
Sequence Shortening

Ac-CSNLSTCMLGRLSQDLHRLQTYPKTDVGANAP-NH2 (Disulfide bridge: Cys1-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KBP-089 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-0891776112-67-4KBP089KBP 089Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorcalcitonin receptorratstype 2 diabetesliver tissueinsulinglucose homeostasisobesityInhibitorinhibitorinhibit

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产品名称：
KBP-089
目录号：
HY-P11610
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