2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. KBP-336

KBP-336 是一种胰淀素和降钙素受体双重激动剂 (DACRA)。KBP-336 具有抗糖尿病和胰岛素增敏特性，可改善糖尿病大鼠的血糖、空间学习和记忆能力，降低血糖水平。KBP-336 也能改善骨关节炎大鼠的疼痛样症状。KBP-336 还可减重减脂。KBP-336 可用于糖尿病、肥胖和关节炎等疾病的研究。

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Custom Peptide Synthesis

KBP-336

KBP-336 Chemical Structure

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KBP-336 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KBP-336 is a dual amylin and calcitonin receptor agonist (DACRA). KBP-336 exhibits antidiabetic and insulin-sensitizing properties, improves glucose levels, spatial learning, and memory in diabetic rats, and reduces blood glucose. KBP-336 also alleviates pain-like symptoms in osteoarthritis rats. KBP-336 also promotes weight and fat reduction. KBP-336 is useful for research on diabetes, obesity, and arthritis[1][2][3].

体内研究
(In Vivo)

KBP-336 (4.5 nmol/kg；皮下注射；每 3 天 1 次；持续 127 天) 可改善糖尿病大鼠的空间学习记忆障碍和血糖，并预防眼部白内障的发生[1]。
KBP-336 (0.5-4.5 nmol/kg；皮下注射；每 72 小时一次；6-8 周) 可改善高脂饮食联合内侧半月板切除术大鼠的疼痛样症状，并降低其体重和脂肪组织[2]。
KBP-336 (4.5 nmol/kg；皮下注射；每 3 天一次；8 周) 在高脂饮食诱导肥胖大鼠中具有减重的活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zucker Diabetic Fatty Rats (male, 6-7 weeks old, fed Purina Laboratory Diet #5008, left untreated for 3 weeks to develop diabetes)[1]
Dosage: 4.5 nmol/kg
Administration: s.c.; every 3 days; 127 days
Result: Significantly improved spatial learning.
Improved fasting blood glucose levels, reduced tAUC of fasting blood glucose and improved HbA1c levels.
Improved glucose tolerance, preserved plasma insulin levels and prevented eye cataract development.
Animal Model: Sprague Dawley rats (high-fat diet-fed with medial meniscectomy)[2]
Dosage: 0.5 nmol/kg; 1.5 nmol/kg; 4.5 nmol/kg
Administration: s.c.; every 72 hours; 6 and 8 weeks
Result: Significantly increased the 50% paw withdrawal threshold (PWT), indicating relieved pain-like symptoms.
Induced significant weight loss and reduced inguinal and perirenal adipose tissue masses at doses of 1.5 and 4.5 nmol/kg.
Did not affect body weight or fat depots, still effectively alleviated pain at 0.5 nmol/kg dose.
Animal Model: Sprague-Dawley rats (male, 5-6 weeks, high-fat diet)[3]
Dosage: 4.5 nmol/kg
Administration: s.c.; every 3 days; 8 weeks
Result: Significantly reduced body weight and adiposity, improved glucose homeostasis, delayed gastric emptying.
Increased oligomycininduced leak respiration and the activity of citrate synthase and β-hydroxyacetyl-CoA-dehydrogenase.
分子量

3917.50

Formula

C172H287N43O56S2
Sequence

Ac-Cys-Ala-Ser-Leu-Ser-Thr-Cys-{Aib}-Leu-Gly-Arg-Leu-Ser-Ala-Glu-Leu-His-Lys(AEEA-AEEA-γGlu-C18 diacid)-Ala-Thr-Tyr-Pro-Lys-Thr-Asp-Val-Gly-Ala-Asn-Ala-Pro-NH2
Sequence Shortening

Ac-CASLSTC-{Aib}-LGRLSAELH-Lys(AEEA-AEEA-γGlu-C18 diacid)-ATYPKTDVGANAP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KBP-336 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KBP-336KBP336KBP 336Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorbody weightantinociceptionZucker Diabetic Fatty ratsdiabetesobesityInhibitorinhibitorinhibit

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目录号：
HY-P11629
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