2. TGF-beta/Smad Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. TGF-β Receptor Hepcidin Ferroportin
  4. KY1070

KY1070 是一种全人源抗 BMP6 抗体，其对人源靶点的 Kd 为 0.00014 μM，对 BMP6 具有高度特异性 (与 BMP 家族相关成员无交叉反应)，可抑制 BMP6 诱导的 BMP 受体异二聚化、铁调素 (Hepcidin) 表达 。KY1070 能调节红系前体细胞上铁转运蛋白 (Ferroportin) 的表达，并加速红细胞生成。在啮齿动物贫血模型中，KY1070 与促红细胞生成素 (EPO) 联用时可减少 EPO 剂量；此外，它还能提高小鼠慢性肾脏病相关性贫血对 EPO 的敏感性。KY1070 可用于慢性病贫血 (anemia of chronic disease) 的研究 [1] [2]。

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KY1070

KY1070 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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KY1070 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

查看所有亚型
ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 μM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].

反应种属

Human
IC50 & Target

hBMP6

0.00014 μM (Kd)

体外研究
(In Vitro)

KY1070 (初始终浓度为 600 nM) 可结合重组人 BMP6，中和多个物种的 BMP6，与其他 BMP 无交叉反应性，并能抑制 BMPR 异二聚化 (Kd = 140 pM) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KY1070 相关抗体:
体内研究
(In Vivo)

KY1070 (3 mg/kg；单次注射) 可调节 Bmp6 野生型小鼠的铁稳态 [1]。
KY1070 (0.1-3 mg/kg) 可提高慢性肾病 (CKD) 雄性 C57BL/6N 小鼠对 EPO 的敏感性 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bmp6 wild-type mice; Bmp6-deficient mice[1]
Dosage: 3 mg/kg
Administration: single injection
Result: Significantly decreased hepatic Hamp mRNA and increased plasma iron levels in Bmp6-wt mice; showed no effect on hepatic Hamp mRNA or plasma iron levels in Bmp6^-/- mice
基因 ID

654  [NCBI]

Accession

P22004
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KY1070 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY1070KY 1070KY-1070TGF-β ReceptorHepcidinFerroportinTransforming growth factor beta receptorsIron-regulated Transporter 1anemia of chronic diseaseBone Morphogenetic Protein 6C57BL/6N miceferroportinACDBmp6 wild-type miceLewis ratshepcidinEPOCKDerythroid precursor cellsBMP6Bmp6 deficient micerodent anemia modelsHamp promoterInhibitorinhibitorinhibit

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目录号：
HY-P991881
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