2. Stem Cell/Wnt Cell Cycle/DNA Damage
  3. Wnt β-catenin CDK
  4. KY19334

KY19334 是一种 CXXC5-DVL 抑制剂。KY19334 可通过抑制 CXXC5-Dvl 的相互作用来激活Wnt/β-连环蛋白通路。KY19334 可通过抑制 CDK1 来抑制癌细胞的增殖、迁移、侵袭和转化。KY19334 能够加速伤口愈合并发挥再生作用。KY19334 可用于癌症、炎症、神经系统和代谢性疾病的研究，如皮肤鳞状细胞癌和糖尿病。

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KY19334

KY19334 Chemical Structure

CAS No. : 2319609-67-9

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KY19334 相关抗体

Top Publications Citing Use of Products

查看 Wnt 亚型特异性产品:

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Wnt1 Wnt3 Wnt5 Wnt7

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KY19334 is a CXXC5-DVL inhibitor. KY19334 can activate the Wnt/β-catenin pathway by inhibiting CXXC5-Dvl interaction. KY19334 can inhibit cancer cells proliferation, migration, invasion and transformation by inhibiting CDK1. KY19334 can accelerate wound healing and exert regenerative effects. KY19334 can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as cutaneous squamous cell carcinoma and diabetes[1].

IC50 & Target[1]

CDK1

 

体外研究
(In Vitro)

KY19334 (5 μM, 72 h) 可抑制人皮肤鳞状细胞癌 (cSCC) 细胞 HSC-1 和 HSC-5 的增殖，但对正常角质形成细胞 HaCaT 无明显增殖抑制作用[1]。
KY19334 (5 μM, 24 h) 可显著抑制 HSC-1 和 HSC-5 细胞的迁移和侵袭[1]。
KY19334 (5 μM, 2 weeks) 可抑制 HSC-1 和 HSC-5 细胞的集落形成[1]。
KY19334 (5 μM, 24 h) 可下调 HSC-1 和 HSC-5 细胞中 CDK1 的表达，并抑制 Wnt/β-连环蛋白信号通路[1]。
KY19334 (1 mM, 7-16 days) 可激活糖尿病小鼠创面组织角质形成细胞、血管内皮细胞和成纤维细胞中的 Wnt/β-连环蛋白信号通路[2]。
KY19334 (1 mM, 7 days) 可促进糖尿病小鼠创面组织中 CD31+ 血管内皮细胞血管生成相关蛋白的表达[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KY19334 相关抗体:

Western Blot Analysis[1]

Cell Line: HSC-1 and HSC-5 cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Reduced CDK1 levels by approximately 50%.
Did not alter the expression of CDK4.
Increased the phosphorylation of β-catenin at Ser33/37/Thr41.
Downregulated the expression of downstream target genes c-Myc and Cyclin D1.

ELISA Assay[2]

Cell Line: CD31+ vascular endothelial cells of diabetic mouse wound tissues
Concentration: 1 mM
Incubation Time: 7 days
Result: Increased VEGFA secretion (approximately 80%), CD31+ capillary density (approximately 75%) and VEGFR2 protein level (approximately 65%).
Downregulated the expression of anti-angiogenic factor Serpin F1 (PEDF) (approximately 50%).
体内研究
(In Vivo)

KY19334 (2 mM，局部应用，每次 TPA 前 30 分钟) 可显著抑制 DMBA (HY-W011845) 和 TPA 诱导的 C57BL/6 小鼠皮肤癌的发生[1]。
KY19334 (1 mM，局部应用，连续 16 天每日一次) 可促进糖尿病 C57BL/6 小鼠的伤口愈合[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DMBA (HY-W011845)/TPA-induced skin cancer C57BL/6 mice models[1]
Dosage: 2 mM
Administration: Topically application, 30 mins before each TPA
Result: Decreased tumor numbers and average size.
Improved tumor grading.
Reduced the proportions of hyperplasia, papilloma and carcinoma in situ.
Decreased the proportion of SCC.
Downregulated the expressions of CDK1, β-catenin, c-Myc, Cyclin D1 and PCNA in tumor tissues.
Upregulated the expressions of tumor suppressor proteins p21Cip/WAF and p27.
Animal Model: HFD (high fat diet)+STZ (HY-13753)-induced diabetic C57BL/6 mice and db/db mice[2]
Dosage: 1 mM
Administration: Topically application, daily for 16 days
Result: Increased the wound closure rate.
Enhanced collagen deposition in wound tissues.
Restored the proliferation of Keratin14+ keratinocytes and CD31+ capillary density.
Increased nuclear β-catenin expression.
分子量

307.30

Formula

C17H13N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KY19334 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY193342319609-67-9KY 19334KY-19334Wntβ-cateninCDKBeta cateninCyclin dependent kinaseCXXC5DVLCDK1Cutaneous squamous cell carcinomaDiabetesHSC-1HSC-5DMBATPAInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-178227
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