2. GPCR/G Protein
  3. Angiotensin Receptor
  4. L-163958

L-163958 是一种高效、口服有效、平衡型血管紧张素 II 受体 (AII receptor) 拮抗剂。L-163958 对 AT1 和 AT2 具有平衡的高亲和力，其在兔主动脉 (AT1)、大鼠中脑 (AT2)、人肾上腺 (AT1)、人肾上腺 (AT2) 的 IC50 分别为 0.16、0.12、0.50 和 0.64 nM。L-163958 在大鼠中具有强大的抑制升压活性。L-163958 可用于研究高血压及相关心血管疾病。

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L-163958

L-163958 Chemical Structure

CAS No. : 168473-51-6

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L-163958 相关抗体

Top Publications Citing Use of Products

查看 Angiotensin Receptor 亚型特异性产品:

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AT1 Receptor AT2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases[1].

IC50 & Target[1]

AT1 Receptor

0.16 nM (IC50)

AT2 Receptor

0.12 nM (IC50)

分子量

730.64

Formula

C33H37BrFN5O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-163958 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-163958168473-51-6L163958L 163958Angiotensin Receptorangiotensin II receptor antagonistAT1AT2balanced inhibitortriazolinonehypertensionrenin-angiotensin systemoral activitystructure-activity relationshipInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-114284
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