2. Anti-infection
  3. Reverse Transcriptase HIV
  4. L 697661

L 697661 是一种具有口服活性的 HIV-1 逆转录酶抑制剂。

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L 697661

L 697661 Chemical Structure

CAS No. : 135525-78-9

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L 697661 相关抗体

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L 697661 is an orally active HIV-1 reverse transcriptase inhibitor[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C8166 EC50
0.007 μM
Compound: 3
Inhibition of p24 antigen formation in infected C8166-cells
Inhibition of p24 antigen formation in infected C8166-cells
[PMID: 7504733]
C8166 EC50
0.007 μM
Compound: 3
Inhibition of syncytia formation in infected C8166-cells
Inhibition of syncytia formation in infected C8166-cells
[PMID: 7504733]
MT2 CC50
> 10 μM
Compound: L-697661
Cytotoxic concentration against MT-2 cells
Cytotoxic concentration against MT-2 cells
[PMID: 7684450]
MT2 ED50
< 0.3 μM
Compound: L-697661
Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.
Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.
[PMID: 7684450]
MT2 IC50
0.08 μM
Compound: L-697661
Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
[PMID: 7689109]
MT4 EC50
0.007 μM
Compound: 3
Inhibition of reverse transcriptase of HIV-1 (strain RF)-infected MT-4 cells in RPMI 1640 growth medium in MTM assay
Inhibition of reverse transcriptase of HIV-1 (strain RF)-infected MT-4 cells in RPMI 1640 growth medium in MTM assay
[PMID: 7504733]
MT4 EC50
> 10 μM
Compound: 3
Inhibition of HIV-1 (strain A17)-infected MT-4 cells
Inhibition of HIV-1 (strain A17)-infected MT-4 cells
[PMID: 7504733]
MT4 ED50
0.065 μM
Compound: L-697661
Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells
Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells
[PMID: 8863804]
MT4 ED50
0.065 μM
Compound: L-697661
Antiviral activity was determined against wild type HIV-1 in MT-4 cells infected with HIV-1 IIIB using an XTT assay
Antiviral activity was determined against wild type HIV-1 in MT-4 cells infected with HIV-1 IIIB using an XTT assay
[PMID: 9873380]
MT4 ED50
0.85 μM
Compound: L-697661
Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells
Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells
[PMID: 8863804]
MT4 ED50
0.85 μM
Compound: L-697661
Antiviral activity was determined against HIV-1 (clone 118) in MT-4 cells infected with HIV-1 IIIB using an XTT assay
Antiviral activity was determined against HIV-1 (clone 118) in MT-4 cells infected with HIV-1 IIIB using an XTT assay
[PMID: 9873380]
MT4 ED50
> 11 μM
Compound: L-697661
Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells
Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells
[PMID: 8863804]
MT4 ED50
> 11 μM
Compound: L-697661
Antiviral activity was determined against HIV-1 (clone 90) in MT-4 cells infected with HIV-1 IIIB using an XTT assay
Antiviral activity was determined against HIV-1 (clone 90) in MT-4 cells infected with HIV-1 IIIB using an XTT assay
[PMID: 9873380]
MT4 IC50
0.0017 μg/mL
Compound: L-697661
Antiviral activity against HIV-1 (strain RF) infected MT-4 cells
Antiviral activity against HIV-1 (strain RF) infected MT-4 cells
[PMID: 7538590]
MT4 IC50
0.0023 μg/mL
Compound: L-697661
Antiviral activity against HIV-1 resistant to 2-(2-Benzoyl-4-chloro-phenyl)-N-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-acetamide in MT-4 cells
Antiviral activity against HIV-1 resistant to 2-(2-Benzoyl-4-chloro-phenyl)-N-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-acetamide in MT-4 cells
[PMID: 7538590]
MT4 IC50
100 μg/mL
Compound: L-697661
Cytotoxicity against uninfected MT-4 cells
Cytotoxicity against uninfected MT-4 cells
[PMID: 7538590]
MT4 IC50
100 μg/mL
Compound: L-697661
Cytotoxicity against uninfected MT-4 cells
Cytotoxicity against uninfected MT-4 cells
[PMID: 7538590]
PBMC CC50
> 10 μM
Compound: L-697661
Cytotoxic concentration against PBMC cells
Cytotoxic concentration against PBMC cells
[PMID: 7684450]
分子量

352.22

Formula

C16H15Cl2N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L 697661 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 697661135525-78-9L697661L-697661Reverse TranscriptaseHIVHuman immunodeficiency virusorally activeInhibitorinhibitorinhibit

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产品名称：
L 697661
目录号：
HY-105216
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