2. Immunology/Inflammation
  3. FAP
  4. L-Ala-BPA

L-Ala-BPA 是一种硼递送剂。L-Ala-BPA 可通过 PEPT1/2 和 LAT-1 (SLC7A5) 通路被转运至肿瘤细胞内，并可被包括 FAP 在内的内源性蛋白酶在全身快速切割，生成 L-BPA (HY-W087830)。L-Ala-BPA 具有抗肿瘤活性，可用于硼中子俘获治疗 (BNCT) 的研究。

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L-Ala-BPA

L-Ala-BPA Chemical Structure

CAS No. : 2941355-27-5

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L-Ala-BPA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT)[1].

体外研究
(In Vitro)

L-Ala-BPA (2 h) 通过 PEPT1/2 转运通路介导 AsPC-1 细胞中剂量依赖性的硼摄取[1]。
L-Ala-BPA (2 h) 通过 LAT-1 转运途径介导 FaDu 细胞中剂量依赖性的硼摄取[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ala-BPA 相关抗体:
体内研究
(In Vivo)

L-Ala-BPA (200 mg/kg；静脉注射；单次推注剂量；中子照射前 90 分钟) 并辅以 12 分钟中子照射，可在接种同源 CT26 结肠癌的 BALB/c 小鼠中实现完全且持久的肿瘤控制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon carcinoma BALB/c mice[1]
Dosage: 200 mg/kg
Administration: i.v.; single bolus dose; 90 minutes prior to neutron irradiation
Result: Induced complete and durable tumor control through the study endpoint.
Produced a 34% growth delay in non-irradiated abscopal tumors.
分子量

280.08

Formula

C12H17BN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-Ala-BPA 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ala-BPA2941355-27-5FAPFibroblast activation proteinAsPC-1 cellscolon carcinomaCT26 colon carcinomaBALB/c miceboron neutron capture therapyPEPT1/2LAT-1 (SLC7A5)FaDu cellshypopharyngeal cancerInhibitorinhibitorinhibit

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