2. Metabolic Enzyme/Protease Anti-infection GPCR/G Protein
  3. Bacterial Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)
  4. Lactic acid potassium

Lactic acid potassium  (Synonyms: 乳酸钾; DL-Lactic acid potassium; E-270 potassium)

目录号: HY-B2227C 含量: 60.8%
COA 产品使用指南 技术支持

Lactic acid (DL-Lactic acid) potassium 是一种羟基羧酸受体 1 (HCAR1) 激活剂和诱导赖氨酸残基乳酰化的表观遗传调节剂。Lactic acid potassium 是糖酵解终产物，弥补了糖酵解和氧化磷酸化之间的差距。Lactic acid potassium 是一种肿瘤代谢物，在抗肿瘤免疫中具有乳酸的免疫保护作用。Lactic acid potassium 还具有抗菌活性，可用作食品保鲜剂。

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Lactic acid potassium

Lactic acid potassium Chemical Structure

CAS No. : 996-31-6

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100 g ￥144
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Customer Review

Other Forms of Lactic acid potassium:

Lactic acid potassium 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 35 篇科研文献

IP
WB
IF
RT-PCR

    Lactic acid potassium purchased from MCE. Usage Cited in: Redox Biol. 2025 Apr:81:103553.  [Abstract]

    Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.

    Lactic acid potassium purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Co-IP detected the effect of lactate on YY1 protein lactylation modification.

    Lactic acid potassium purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144.  [Abstract]

    Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.

    Lactic acid potassium purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Mar 20;16(1):193.  [Abstract]

    Lactate sodium (5-15 mM; 24 h) ​​results​​ in increased H4K12la (red) levels in CCSCs compared to the control group.

    Lactic acid potassium purchased from MCE. Usage Cited in: J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.  [Abstract]

    Lactate sodium increases IGF-1R levels in PI-resistant KAS-6/1 and U266 cells.

    Lactic acid potassium purchased from MCE. Usage Cited in: Cell Res. 2023 Sep;33(9):679-698.  [Abstract]

    Lactate (NALA) (300 mM; 24 h) significantly upregulates α-MHC K1897 lactylation in H9c2 cells.

    Lactic acid potassium purchased from MCE. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309.

    The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative[3].

    IC50 & Target

    Bacterial[2]
    体外研究
    (In Vitro)

    Lactic acid (20 mM；24、48 小时) potassium 导致细胞增殖和迁移显着减少，作用并将细胞代谢转变为氧化磷酸化[1]。
    Lactic acid (20 mM；24 小时) potassium 显示 MCT1 和 HCAR1 的蛋白质和 mRNA 表达水平增加[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Lactic acid potassium 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24, 48 h
    Result: Inhibited cell proliferation and migration.

    Western Blot Analysis[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Showed an increase in the protein expression levels of MCT1 and HCAR1

    RT-PCR[1]

    Cell Line: Uveal melanoma 92.1 cells
    Concentration: 20 mM
    Incubation Time: 24 h
    Result: Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
    体内研究
    (In Vivo)

    Lactic acid (1.6 g/kg；pH 7.4；皮下注射；每天一次；第 8 天至 30 天) potassium 在 MC38 结肠癌模型中显示出 CD8+ T 细胞依赖性肿瘤生长抑制作用[2]。
    Note: 动物体内给药前需要将工作液 PH 调至 7.4 左右。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female C57BL/6 mice with MC38 colon cancer cells[2]
    Dosage: 1.6 g/kg
    Administration: Subcutaneous; daily from Day 8 to 30 days
    Result: Significantly suppressed tumor growth.
    Clinical Trial
    分子量

    128.17

    Formula

    C3H5KO3
    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    中文名称

    乳酸钾
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 50 mg/mL (390.11 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 7.8021 mL 39.0107 mL 78.0214 mL
    5 mM 1.5604 mL 7.8021 mL 15.6043 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 60.8%

    COA (260 KB)

    产品使用指南 (1538 KB)
    参考文献

    Lactic acid potassium 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 7.8021 mL 39.0107 mL 78.0214 mL 195.0534 mL
    5 mM 1.5604 mL 7.8021 mL 15.6043 mL 39.0107 mL
    10 mM 0.7802 mL 3.9011 mL 7.8021 mL 19.5053 mL
    15 mM 0.5201 mL 2.6007 mL 5.2014 mL 13.0036 mL
    20 mM 0.3901 mL 1.9505 mL 3.9011 mL 9.7527 mL
    25 mM 0.3121 mL 1.5604 mL 3.1209 mL 7.8021 mL
    30 mM 0.2601 mL 1.3004 mL 2.6007 mL 6.5018 mL
    40 mM 0.1951 mL 0.9753 mL 1.9505 mL 4.8763 mL
    50 mM 0.1560 mL 0.7802 mL 1.5604 mL 3.9011 mL
    60 mM 0.1300 mL 0.6502 mL 1.3004 mL 3.2509 mL
    80 mM 0.0975 mL 0.4876 mL 0.9753 mL 2.4382 mL
    100 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9505 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lactic acid996-31-6DL-Lactic acidE-270乳酸钾E270E 270BacterialEndogenous MetaboliteHydroxycarboxylic Acid Receptor (HCAR)hydroxycarboxylic acid receptor 1HCAR1epigeneticlysine residues lactylationglycolysisoxidative phosphorylationoncometaboliteanti-tumorInhibitorinhibitorinhibit

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