2. Metabolic Enzyme/Protease
  3. MetAP
  4. LAF389

LAF389，一种苯甲酰胺 B 类似物，是一种甲硫氨酸氨肽酶 (MetAps) 抑制剂，对 MetAp2 的 IC50 值为 800 nM。LAF389 具有抗增殖和抗血管生成特性，能够抑制肿瘤细胞生长。LAF389 可用于癌症研究。

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LAF389

LAF389 Chemical Structure

CAS No. : 270902-51-7

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LAF389 相关抗体

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MetAP2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LAF389, a benaamide B analogue, is a methionine aminopeptidases (MetAps) inhibitor with an IC50 of 800 nM for MetAp2. LAF389 has both antiproliferative and antiangiogenetic properties and can inhibit tumor cells growth. LAF389 can be used for the research of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
13 nM
Compound: LAF389
Antiproliferative activity against human A549 cells after 96 hrs
Antiproliferative activity against human A549 cells after 96 hrs
[PMID: 28185457]
HCT-116 IC50
23 nM
Compound: LAF389
Antiproliferative activity against human HCT116 cells after 96 hrs
Antiproliferative activity against human HCT116 cells after 96 hrs
[PMID: 28185457]
MDA-MB-435 IC50
40 nM
Compound: LAF389
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 28185457]
分子量

498.61

Formula

C25H42N2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LAF389 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAF389270902-51-7LAF 389LAF-389MetAPMethionine Aminopeptidasemethionine aminopeptidasesMetApsantiproliferativeantiangiogenetictumorcancerInhibitorinhibitorinhibit

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产品名称：
LAF389
目录号：
HY-118953
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