2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. LASSBio-2382

LASSBio-2382 是一种双重 ROCK1/ROCK2 抑制剂，其针对 ROCK1 的 IC50 为 0.005 μM，针对 ROCK2 的 IC50 为 0.003 μM。LASSBio-2382 可抑制癌细胞的活力与迁移。LASSBio-2382 可用于三阴性乳腺癌的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

LASSBio-2382

LASSBio-2382 Chemical Structure

CAS No. : 2487752-24-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

LASSBio-2382 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LASSBio-2382 is a dual ROCK1/ROCK2 inhibitor with ROCK1 IC50 of 0.005 μM and ROCK2 IC50 of 0.003 μM. LASSBio-2382 inhibits viability and migration of cancer cells. LASSBio-2382 can be used for the research of triple-negative breast cancer[1].

IC50 & Target[1]

ROCK1

0.05 μM (IC50)

ROCK2

0.03 μM (IC50)

体外研究
(In Vitro)

LASSBio-2382 (Compound 17) 可在无细胞生化实验中强效抑制纯化的 ROCK1 (IC50 = 0.005 μM) 和 ROCK2 (IC50 = 0.003 μM)[1]。
LASSBio-2382 在 PAMPA-BBB 实验中不溶，无法测定其血脑屏障通透性[1]。
LASSBio-2382 (30 μM; 24 h) 可使 MDA-MB-231 细胞活力降低 28.8%[1]。
LASSBio-2382 (0.1-100 μM; 24 h) 以剂量依赖方式抑制 MDA-MB-231 细胞迁移；10 μM 浓度下其可将伤口闭合率降至 <50%，30 μM 浓度下可降至 <25%，而 100 μM 浓度下可观察到沉淀现象[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LASSBio-2382 相关抗体:

Cell Migration Assay[1]

Cell Line: MDA-MB-231 human triple-negative breast adenocarcinoma cells
Concentration: 0.1 μM, 10 μM, 30 μM, 100 μM
Incubation Time: 24 h
Result: Showed wound closure comparable to the control at 0.1 μM.
Reduced wound closure to less than 50% relative to the control at 10 μM.
Reduced wound closure to below 25% relative to the control at 30 μM.
Showed similar inhibition to 30 μM at 100 μM, with precipitation observed.
分子量

317.34

Formula

C18H15N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LASSBio-2382 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LASSBio-23822487752-24-7LASSBio2382LASSBio 2382ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKtriple-negative breast cancer cellstriple-negative breast cancerROCK1Rho/ROCK pathwayROCK2MDA-MB-231 cellInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
LASSBio-2382
目录号：
HY-181582
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z