2. Metabolic Enzyme/Protease
  3. Liposome
  4. LCA-H10

LCA-H10 是一种石胆酸-组氨酸十肽偶联物，是一种生物相容性脂质纳米颗粒 (LNP) 添加剂，可降低可电离脂质比例，发挥内涵体逃逸诱导剂的作用，并增强 siRNA 的包封效果。将 LCA-H10 掺入 LiLNP-LH 后，静脉注射可增加小鼠体内 LNP 的肝脏蓄积量，并降低小鼠血清中的促炎细胞因子 (IL-6、TNF、IL-1β) 水平。LCA-H10 可用于前列腺癌的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

LCA-H10

LCA-H10 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

LCA-H10 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LCA-H10 is a lithocholic acid-histidine decapeptide conjugate, a biocompatible lipid nanoparticle (LNP) additive that reduces ionizable lipid proportions, functions as an endosomal escape inducer, and enhances siRNA encapsulation. LCA-H10 increases hepatic accumulation of LNPs in mice after intravenous injection when incorporated into LiLNP-LH and reduces proinflammatory cytokines (IL-6, TNF, IL-1β) in mouse serum. LCA-H10 can be used for the research of prostate cancer[1].

体外研究
(In Vitro)

LiLNP-LH (含 LCA-H10)(0-187.8 nM siRNA；5 h + 43 h) 在 PC3-GFP 细胞中展现出比 LiLNP 和 LiLNP-H 更强的基因沉默活性，其 IC50为 216.9 nM[1]。
LiLNP-LH (含有 LCA-H10) (0.3 μg/mL siRNA (PC3); 1.5 μg/mL siRNA (HepG2); 5-6 h) 在 HepG2 细胞中的细胞内摄取水平与 HiLNP 相当，在 PC3 细胞中的摄取水平则与 LiLNP 相近[1]。
LiLNP-LH (含 LCA-H10)(摩尔比 0.9%) 实现了 83.7% 的高 siRNA 包封效率，尽管其可电离脂质占比较低，但该效率可与 HiLNP 相媲美[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LCA-H10 相关抗体:
体内研究
(In Vivo)

LiLNP-LH (40 μg-2 mg/kg siRNA；静脉注射) 在健康 C57BL/6 小鼠中，与 HiLNPs 相比可使 siRNA 的肝脏富集水平提升 1.6 倍，并将炎性细胞因子的诱导水平降低 15-30 倍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (6 weeks old, female)[1]
Dosage: 40 μg siRNA per mouse (biodistribution); 2 mg/kg siRNA (cytokine analysis)
Administration: i.v.
Result: Exhibited 4.6× 10¹⁰ total flux in the liver (1.6-fold higher than HiLNPs) and 50.4 × 10² RFI/mg organ in liver homogenates. Reduced serum IL-6 levels to 144.1 pg/mL (30.6-fold lower than HiLNPs), TNF levels by 29.9-fold, and IL-1β levels by 14.5-fold compared to HiLNPs.
分子量

1747.97

Formula

C84H110N30O13
Sequence

LCA-His-His-His-His-His-His-His-His-His-His
Sequence Shortening

LCA-HHHHHHHHHH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LCA-H10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LCA-H10Liposomeendosomal escape inducerprostate cancerHepG2 cellsendosomal membrane destabilizationlipid nanoparticlesiRNAproinflammatory cytokinesmicellar structurescytoplasmPC3-GFP cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
LCA-H10
目录号：
HY-P11614
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z