2. Protein Tyrosine Kinase/RTK TGF-beta/Smad Stem Cell/Wnt
  3. Anaplastic lymphoma kinase (ALK) TGF-beta/Smad
  4. LDN-193688

LDN-193688 是一种 ALK2 抑制剂，其对于 ALK1、ALK2、ALK3、ALK4、ALK5 的 IC₅₀ 分别为 104、18、235、1530、1080 nM。LDN-193688 (Compound 26) 抑制骨形态发生蛋白 4 (BMP4) 诱导的 SMAD1/5/8 磷酸化，其 IC₅₀ 为 2.6 μM。

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LDN-193688

LDN-193688 Chemical Structure

CAS No. : 1062368-51-7

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LDN-193688 相关抗体

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  • 生物活性

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生物活性

LDN-193688 is a ALK2 inhibitor, with IC₅₀ values of 104, 18, 235, 1530, and 1080 nM against ALK1, ALK2, ALK3, ALK4, and ALK5, respectively. LDN-193688 (Compound 26) inhibits bone morphogenetic protein 4 (BMP4)-induced phosphorylation of SMAD1/5/8, with an IC₅₀ of 2.6 μM[1][2].
分子量

352.39

Formula

C22H16N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LDN-193688 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LDN-1936881062368-51-7LDN193688LDN 193688Anaplastic lymphoma kinase (ALK)TGF-beta/SmadAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Transforming growth factor betaTGF-β/Activin type I receptorsrecombinant ALK2ALK5ALK3cell-free kinase assayALK1BMP type I receptorsALK4ALK2kinase activityInhibitorinhibitorinhibit

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产品名称：
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目录号：
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