2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. LIG48

LIG48 是 ROS1 激酶结构域及其突变体 (G2032R ROS1 激酶结构域) 的抑制剂。LIG48 在突变型和野生型 ROS1 激酶结构域内均有抑制作用。LIG48 可用于非小细胞肺癌的研究。

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LIG48

LIG48 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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LIG48 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LIG48 is ROS1 kinase domain and its mutant (G2032R ROS1 kinase domain) inhibitor. LIG48 remains within the mutated and wild-type ROS1 kinase domains. LIG48 can be used for the study of non-small cell lung cancer[1].

体外研究
(In Vitro)

LIG48 对野生型 ROS1 表现出最高的结合亲和力 (-9.272 kcal/mol)，对 G2032R 突变体 ROS1 的结合亲和力为 -8.9 kcal/mol[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LIG48 相关抗体:
分子量

451.48

Formula

C22H25N7O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LIG48 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIG48LIG 48LIG-48ROS KinaseComputer-aided-drug-designCrizotinibMolecular dynamics simulationsDockingProtooncogene tyrosine-protein kinase ROSProtein simulationMACCSInhibitorinhibitorinhibit

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