2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Cholinesterase (ChE) Histamine Receptor
  4. LINS05414

LINS05414 是一种具有抗胆碱酯酶 (Cholinesterase) 和金属螯合活性的组胺 H3 受体配体。LINS05414 对乙酰胆碱酯酶 (pIC50 为 4.03) 和丁酰胆碱酯酶 (pIC50 为 3.83) 具有抑制活性，对人组胺 H3 受体的 pKi 为 6.37。LINS05414 可螯合铜离子、亚铁离子和铁离子。LINS05414 可调节神经递质的释放。LINS05414 可用于神经退行性疾病的研究。

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LINS05414

LINS05414 Chemical Structure

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LINS05414 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LINS05414 is a histamine H3 receptor ligand with antiCholinesterase and metal chelating activities. LINS05414 exhibits inhibitory activity against acetylcholinesterase (pIC50 = 4.03) and butyrylcholinesterase (pIC50 = 3.83), with a pKi of 6.37 for human histamine H3 receptors. LINS05414 chelates copper ions, ferrous ions and ferric ions. LINS05414 regulates the release of neurotransmitters. LINS05414 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

H3 receptor

 

AChE

 

BChE

 

体外研究
(In Vitro)

LINS05414 (90 min at 25 °C) 可结合 HEK-293-hH3R 细胞膜中的组胺 H3 受体，其 pKi 为 6.37[1]。
LINS05414 (10 min at 37 °C) 抑制电鳗乙酰胆碱酯酶，其 pIC50 为 4.03，抑制马血清丁酰胆碱酯酶，其 pIC50 为 3.83[1]。
LINS05414 (50 μM) 可螯合 Fe2+、Fe3+ 和 Cu2+ 离子[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LINS05414 相关抗体:
分子量

375.47

Formula

C22H25N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LINS05414 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LINS05414LINS 05414LINS-05414Cholinesterase (ChE)Histamine Receptorhistamine H3 receptor ligandantiCholinesterasemetal chelating activitiesHEK-293-hH3R cell
Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181597
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