2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from S. enterica serotype enteritidis

Lipopolysaccharides, from S. enterica serotype enteritidis  (Synonyms: LPS, from Salmonella enterica (Serotype enteritidis))

目录号: HY-D1056C1
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Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis 是来源于肠道沙门氏菌 (S. enterica) 血清型的致肠炎脂多糖内毒素和 TLR-4 激活剂，是一种 S 型 LPS，可激活免疫系统的致病相关分子模式 (PAMP) 和诱导细胞分泌迁移体。Lipopolysaccharides, from S. enterica serotype enteritidis 具有典型的 3 部分结构：O 抗原、核心寡糖和脂质 A。Lipopolysaccharides, from S. enterica serotype enteritidis 可诱导全身炎症反应，升高血浆中的 TNF-α、IFN-γ、IL-6、IL-10 以及硝酸盐水平。
建议配制 ≥2 mg/mL 母液，并保证充分混合溶解。由于 LPS 具有吸附特性，分装保存时需使用低吸附离心管。

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Lipopolysaccharides, from S. enterica serotype enteritidis

Lipopolysaccharides, from S. enterica serotype enteritidis Chemical Structure

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Lipopolysaccharides, from S. enterica serotype enteritidis 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma[1][2].
It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.

IC50 & Target

TLR-4[2]
体外研究
(In Vitro)

Note:
1. 为了保持 LPS 的完整性，建议将 LPS 溶液存放在硅烷化容器中。因为 LPS 可以粘附在塑料和某些类型的玻璃上，尤其是在浓度低于 0.1 mg/mL 时。如果 LPS 浓度超过 1 mg/mL，这种吸附作用相对较小，建议配制 ≥2 mg/mL 母液，并保证充分混合溶解。如果使用玻璃容器，请确保使用前充分混合至少 30 分钟，以重新溶解任何吸附在管壁的 LPS。
2. LPS 是一种能在溶液中形成不同尺寸胶束的分子，分子量不固定，储备液及工作液可直接配制成质量浓度 (mg/mL, μg/mL, etc.)。
3. LPS 溶于水或 PBS 后可能会观察到均匀的浑浊溶液，如需过滤除菌，请勿直接过滤储备液，建议稀释成工作液之后用 0.22 μm 的滤膜过滤除菌。

Lipopolysaccharides, from S. enterica serotype enteritidis 介导的氧化应激程度比病原体的鞭毛蛋白 (Flagellin) 更轻，并只引发肾脏而非肝脏损伤。Lipopolysaccharides, from S. enterica serotype enteritidis 在小鼠肺中多形核中性粒细胞的滞留（髓过氧化物酶活性增加），而只有 LPS 会在肠道中募集中性粒细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from S. enterica serotype enteritidis 相关抗体:
体内研究
(In Vivo)

Lipopolysaccharides, from S. enterica serotype enteritidis (4 mg/kg, 0.2 mL；IV；单剂量) 在小鼠模型中，诱导 TNF-α、IFN-γ、IL-6 和 IL-10 显著释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (8 to 10 weeks old, 25 to 30 g)[1]
Dosage: (1) 100 μg (4 mg/kg), given in 0.2 mL of vehicle (10 mM PBS [pH 7.4]). (2) 20 μg/mous or 10 μg of LPS plus 10 μg of flagellin/mouse.
Administration: Intravenous injection, via the tail vein; single dose.
Result: Induced a significant increase in MPO after 8 h in n the liver and kidney.
Decreased the levels of reduced glutathione in tissue in a comparable way in the lung, gut, and kidney.
Compared treatment separately, significantly enhanced the release of both cytokines when injected LPS and flagellin together.
性状

固体

颜色

White to off-white

中文名称

脂多糖,来源于肠沙门氏菌肠炎血清型
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

COA (255 KB)

产品使用指南 (1538 KB)
参考文献

Lipopolysaccharides, from S. enterica serotype enteritidis 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype enteritidisLPS, from Salmonella enterica (Serotype enteritidis)脂多糖,来源于肠沙门氏菌肠炎血清型Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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