2. Neuronal Signaling
  3. Amyloid-β Tau Protein
  4. Lithium orotate

Lithium orotate 是一种口服有效的锂补充剂，结合力低，能够绕过阿尔茨海默病 (AD) 小鼠模型中的淀粉样蛋白 (amyloid) 螯合作用。Lithium orotate 在 AD 小鼠模型和衰老的野生型小鼠中，能阻止 Aβ 斑块的沉积和磷酸化 tau 蛋白的积累，并逆转 AD 病理、神经炎症变化以及记忆丧失。Lithium orotate 可用于酒精中毒和阿尔茨海默病的研究。

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Lithium orotate

Lithium orotate Chemical Structure

CAS No. : 5266-20-6

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Lithium orotate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lithium orotate is an orally active lithium supplement with reduced binding that can bypass amyloid sequestration in AD mice models. Lithium orotate can prevent Aβ plaque deposition and phospho-tau accumulation and reverse AD pathology, neuroinflammatory changes and memory loss in AD mice models and ageing wild-type mice. Lithium orotate can be used for the research of alcoholism and Alzheimer’s disease[1][2].

体外研究
(In Vitro)

Lithium orotate (0-500 μM；作用 16 小时) 与合成人源 Aβ1-42 原纤维及寡聚体的结合能力较低[2]。
Lithium orotate (20-500 μM；预处理 6 小时) 可促进 BV2 小胶质细胞对 Aβ42 的摄取与降解[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lithium orotate 相关抗体:
体内研究
(In Vivo)

Lithium orotate (4.3-430 µM；口服；饮水摄取) 可在 AD 小鼠模型及衰老野生型小鼠中预防并逆转 AD 病理改变与认知衰退[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3xTg mice carried APPSwe and tauP301L
mutant transgenes and ageing wild-type mice[2]
Dosage: 4.3 and 130 µM
Administration: p.o.; in drinking water
Result: Almost completely prevented Aβ plaque deposition and phospho-tau accumulation in 3xTg mice.
Reversed memory loss in 3xTg mice and improved.
Prevented age-related microgliosis, astrogliosis, synapse loss, and cognitive decline in wild-type mice.
分子量

162.03

Formula

C5H3LiN2O4
CAS 号
性状

固体

中文名称

乳清酸锂
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Lithium orotate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lithium5266-20-6乳清酸锂Amyloid-βTau Proteinβ-amyloid peptideAβAbetaneuroinflammationBV2microglial activationamyloid-β plaquephospho-tauInhibitorinhibitorinhibit

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