2. Others Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. Drug Derivative Ephrin Receptor Interleukin Related IFNAR
  4. Lithocholic amide-C2-N(didecane)

Lithocholic amide-C2-N(didecane) (Compound LC10) 是一种 Lithocholic acid (HY-B0172) 类似物。Lithocholic amide-C2-N(didecane) 能在水性环境中自发形成脂质纳米颗粒，穿透皮肤，渗入真皮层，并对银屑病样慢性皮肤炎症发挥抗炎作用。Lithocholic amide-C2-N(didecane) 可抑制角质形成细胞的异常增殖，下调银屑病相关受体EphA2 的 mRNA 表达，并通过抑制 Th17/Th2 炎症通路的激活降低多种促炎因子 (如IL-1α、IL-1β 和IFN-γ) 的血清水平。

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Lithocholic amide-C2-N(didecane)

Lithocholic amide-C2-N(didecane) Chemical Structure

CAS No. : 2768690-22-6

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Lithocholic amide-C2-N(didecane) 相关抗体

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查看 Ephrin Receptor 亚型特异性产品:

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EphA

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway[1].

IC50 & Target[1]

EPHA2

 

IL-1α

 

IL-1β

 

分子量

699.19

Formula

C46H86N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lithocholic amide-C2-N(didecane) 相关分类

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Keywords:

Lithocholic amide-C2-N(didecane)2768690-22-6Drug DerivativeEphrin ReceptorInterleukin RelatedIFNARDrug derivativeILInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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